Abstract Number: VPB0691
Meeting: ISTH 2022 Congress
Theme: Hemophilia and Rare Bleeding Disorders » Hemophilia - Clinical
Background: According to the World Federation of Hemophilia, Brazil has the 3rd largest population of hemophiliacs. Primary prophylaxis was implemented in Brazil from 2009 onwards.
Aims: To compare demographic and clinical Hemophilia A and B patients’ characteristics across São Paulo State.
Methods: São Paulo State Hemovida Web – Coagulopathies registry from 2009 to 2018 quantitative and temporal series analysis.
Results: The prophylaxis program started in 2009. In 10 years, 2045 Hemophilia A (HA) or B (HB) patients were followed and registered at hemophilia centers in São Paulo State. Patients registered increased an average 3.2% per year, and 2015 had the largest number of new patients. Hemovida registered patients are 82.4% HA and 17.6% HB. Age stratum 20 to 39 years had the highest hemophilia prevalence. Overall, 88.9% participated in the long-term primary or secondary prophylaxis program and 6% are only on-demand treatment. Of these, 3.7% registered patients developed immunotolerance. Standardized mortality rates were 2.94 amid the cohort anteceding the program mainly at the 30-39 age stratum and 1.24:1 000 among those currently under prophylaxis, mainly over 60 years.
Conclusion(s): In Brazilian São Paulo State, similar to other countries, HA and HB regular prophylaxis treatment schedule has been, gradually, personalized and decreased morbidity and mortality.
To cite this abstract in AMA style:
Guersoni a, Trindade EM, R Villaça P, Luiz O. 10 Years Comparative Hemophilia Prophylaxis across São Paulo State – Brazil [abstract]. https://abstracts.isth.org/abstract/10-years-comparative-hemophilia-prophylaxis-across-sao-paulo-state-brazil/. Accessed March 22, 2024.« Back to ISTH 2022 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/10-years-comparative-hemophilia-prophylaxis-across-sao-paulo-state-brazil/