Abstract Number: PB2454
Meeting: ISTH 2020 Congress
Background: One of the serious surgical complication after kidney transplantation is Deep Vein Thrombosis (DVT). In kidney transplant recipient there is an imbalance of hemostatic system, leading to persistent hypercoagulable state and increased risk of thrombotic disease.
Aims: Purpose of this case is to discuss about the DVT as a complication of kidney transplantation.
Methods: We report a case of 43 years old male patient with end stage of kidney disease underwent kidney transplantation from living donor. He received Basiliximab as an induction therapy and maintained on tacrolimus, mycophenolate mofetil and steroid. On the third day of transplantation, the patient suffered from pain and edema on the right lower limb. Doppler examination showed partial thrombus of the right external iliac vein and total thrombus of proximal profunda and superficial femoral vein. The laboratory results showed high D Dimmer level (8310 ng/mL). He was treated with unfractionated heparin and underwent catheter-directed thrombolysis (CDT). The patient´s renal function recover after five days of therapy. The creatinine level was getting lower. At one year post kidney transplantation, the patient´s condition remain stable with no limb edema and normal level of serum creatinine.
Results: More than 90% of the DVT in general surgical patients occur within the 1st week after surgery. Most of the early thrombotic events that occur in this setting can be attributed to technical failures, external compression, preexisting asymptomatic DVT, or thrombophilia. The cause of hypercoagulable state in kidney transplant recipients is multifactorial. They include the use of immunosuppressive agents, presence of antiphospholipid antibody, native kidney disease and infection. The high result of D-Dimer supports the diagnosis of Deep vein thrombosis.
Conclusions: This case report presented a DVT after kidney transplantation diagnosed using Doppler and supported with D-Dimer examination. Catheter-Directed Thrombolysis can fix this condition and recover the kidney function.
To cite this abstract in AMA style:Puspitawati I, Kuswadi I, Wardhani Y, Widodo T. A Case Report of Deep Vein Thrombosis after Kidney Transplantation [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/a-case-report-of-deep-vein-thrombosis-after-kidney-transplantation/. Accessed January 27, 2022.
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