Abstract Number: PB1073
Meeting: ISTH 2021 Congress
Background: People who take anticoagulation are assumed to have a higher risk of traumatic brain injury (TBI) after a head injury than those who are not anticoagulated. The aim of this study was to compare the incidence of TBI among anticoagulated head-injured patients to head-injured patients who do not take anticoagulation.
Aims: The aim of this study was to compare the incidence of TBI among anticoagulated head-injured patients to head-injured patients who do not take anticoagulation.
Methods: This was a two-hospital health records review which enrolled head-injured emergency patients with a Glasgow Coma Score (GCS) 13-15 between May and December 2019. Patients were classified as anticoagulant users or non-anticoagulant users. We defined anticoagulant users as those who took warfarin, apixaban, rivaroxaban, edoxaban, dabigatran, low molecular weight heparin, fondaparinux or unfractionated heparin for at least 3 days prior to emergency department (ED) presentation. We defined our outcome, TBI, as the presence of intracranial blood within any intracranial compartment, diffuse axonal injury or isolated skull fracture. We reported TBI diagnosed at the index ED visit, and delayed TBI diagnosed within 30 days. We compare these incidences between anticoagulant users and non-anticoagulant users.
Results: We enrolled 368 patients who were anticoagulant users and 1650 non-anticoagulant users. The mean age of anticoagulant users was 80, 49% were male, non-anticoagulant users was 61, 54% were male. 23/368 (6.3%, 4.2 to 9.3%) anticoagulant users were diagnosed with TBI on initial ED visit and no patient (0.0%, 0.0 to 1.4%) was diagnosed with delayed TBI in the following 30 days. 125/1650 (7.6%, 6.4 to 9.0%) non-anticoagulant users were diagnosed with TBI on initial ED visit and 4 patients (0.3%, 0.1 to 0.7%) were diagnosed with delayed TBI.
Conclusions: This study did not identify a difference in the rate of TBI between anticoagulated and non-anticoagulated head-injured patients.
To cite this abstract in AMA style:Al-Haimus F, Clayton N, Klyn J, de Wit K. A Comparison of the Incidence of Traumatic Brain Injury in Anticoagulated and Non-anticoagulated Head Injured Patients [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/a-comparison-of-the-incidence-of-traumatic-brain-injury-in-anticoagulated-and-non-anticoagulated-head-injured-patients/. Accessed December 7, 2021.
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