Background: This was done as part of a bigger service implementation project sponsored by NNHF to improve the physiotherapy resource for pwh in India.
Aims: Test efficacy of peer reviewed physiotherapy protocols.
Methods: Necessary protocols regarding data security, ethical approval for study, Pwh consent to participate was fulfilled. 3 peer reviewed physiotherapy protocols were developed as interventions. 5 institutes that participated in protocol development were intervention centres. 9 similar capacity centres for physiotherapy facilities who consented were included as Controls. We trained physiotherapists from intervention centres who provided treatment to eligible PWH as per protocols; PWH in control centres underwent routine physiotherapy.
Inclusion: Hemophilia A: 0 – 17 years
Exclusion: Children suffering from other bleeding disorders, muscle bleeds, entrapment neuropathy, associated HIV, Hepatitis-B, Hepatitis-C, on inhibitors, and amputees.
Outcomes: Standard Physical Evaluation, HJHS, FISH and monitoring Bleed episodes.
Data: The physiotherapists providing care recorded data on a web portal. PwH were measured at baseline, 6, 12 weeks.
Analysis: Repeated measures analysis of score for within the group trends and between group comparisons.
Characteristics: 106 and 167 PWH were recruited into the study in intervention and control groups respectively. Both intervention and control groups had similar mean age (10 years), mean weight (30 kgs).
Outcomes: FISH – The scores in each of the components and the total significantly improved within both the intervention and control groups over time. When comparing the two groups, scores improved significantly in the Locomotion component of the intervention group.
HJHS – Improvement noted in HJHS knee scores within both groups, in left ankle scores in intervention group.
Bleed Episodes-Frequency of bleeding was significantly lower in intervention group as compared to control group from baseline to endline.
Conclusions: Intervention group did better for locomotion and ankle joints. Continued treatment with longer follow up will provide evidence for sustained effect.
To cite this abstract in AMA style:Narayan P. A Multi Centre Non-randomised Clinical Trial to Establish the Efficacy of Peer Reviewed Physiotherapy Treatment Protocols among PWH in India [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/a-multi-centre-non-randomised-clinical-trial-to-establish-the-efficacy-of-peer-reviewed-physiotherapy-treatment-protocols-among-pwh-in-india/. Accessed May 18, 2021.
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