Abstract Number: PB0402
Meeting: ISTH 2021 Congress
Background: We report a patient with congenital hypofibrinogenemia showing embryo implantation, continuation of pregnancy, and delivery following the continuous transfusion of dry human fibrinogen preparations.
Aims: [Case report] A 38-year
Methods: [Gene analysis] Genetic anlysis of the DNA base sequences of the PCR products of the Aα, Bβ, and γ chains confirmed heterozygosity, with the nucleotides TGT (normal, wild-type) and CGT (morph), which encoded the 326thamino acid in the γ chain of exon 8. Further, cysteine (normal, wild-type) was replaced with arginine (morph); thus far, no studies have reported this finding.
Results: [Discussion] Although Fbg is not reported to be necessary during implantation in natural pregnancies, herein, implantation was successful in the presence of Fbg levels > 150 mg/dL during embryo transfer.
Conclusions: Fbg levels > 150 mg/dL may be necessary for implantation during embryo transfer in patients with congenital hypofibrinogenemia.
To cite this abstract in AMA style:Seki Y, Ushiki T, Masuko M, Takizawa J, Sone H, Okumura N. A Patient with Congenital Hypofibrinogenemia who Showed Embryo Implantation, Continuation of Pregnancy, and Delivery Following Continuous Transfusion of Dry Human Fibrinogen Preparations [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/a-patient-with-congenital-hypofibrinogenemia-who-showed-embryo-implantation-continuation-of-pregnancy-and-delivery-following-continuous-transfusion-of-dry-human-fibrinogen-preparations/. Accessed September 27, 2023.
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