Abstract Number: VPB1378
Meeting: ISTH 2022 Congress
Background: Non-adherence to thromboprophylaxis treatment with oral anticoagulants (OAC) is a public health problem and may be associated with high mortality rates.
Aims: We sought to synthesize the factors associated with non-adherence to therapy with coumarin derivatives or direct oral anticoagulants.
Methods: A systematic review was performed at electronic databases Medline, Embase, CINAHL, Lilacs and grey literature (Google Scholar, MedNar, OpenGray, ProQuest Dissertations and Theses and hand search). This study was conducted according to Cochrane’s method and PRISMA. The registration on PROSPERO is CRD42020223555.
Results: Overall, 1,270 studies were identified, and nine studies were selected for this review. In hand search, 77 studies were found, but none included. The associated factors with non-adherence were heterogeneous, and some factors were described as both risk and protection for non-adherence, with few variables showing consistent results among the studies. The factors associated only as risk were male sex, hospitalization, bleeding and Charlson score. The variables white race, number of medications in use and polypharmacy, duration of OAC therapy and CHADS2 or CHA2DS2VASc with scores ranging from 2 to ≥5 were cited just as protective factors.
Conclusion(s): Our systematic review showed risk and protective factors associated with non-adherence. In clinical practice, the knowledge on the factors associated with non-adherence is helpful to identifing patients at higher risk of complications that would benefit from individualized interventions.
To cite this abstract in AMA style:Freitas Nunes De Sousa W, Sernizon Guimarães N, Costa Viana C, Machado P, Fonseca Medeiros A, Sousa Vianna M, Pedra De Souza R, Margotto Bartollo C, Praxedes M, Parreiras Martins M. A systematic review of factors associated with non-adherence to the use of coumarin derivatives or direct oral anticoagulants [abstract]. https://abstracts.isth.org/abstract/a-systematic-review-of-factors-associated-with-non-adherence-to-the-use-of-coumarin-derivatives-or-direct-oral-anticoagulants/. Accessed March 4, 2024.
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