Abstract Number: PB2558
Meeting: ISTH 2020 Congress
Background: The association between congenital thrombophilia and pregnancy loss has been debated in several studies with conflicting results.
Aims: To evaluate the prevalence of both non-O blood group type and inherited thrombophilia (e.g antithrombin, protein S and C deficiencies, factor V Leiden and prothrombin variant) in a group of healthy women with a personal history of miscarriage.
Methods: A group of 156 women with a personal history of abortion were enrolled among non-related caregivers of patients hospitalized in our Medical Department between June and December 2019. Seven hundred twelve healthy women without a personal history of miscarriage were recruited among blood donors as controls. Age below 18 yrs, personal history of venous and/or arterial thrombosis or acquired thrombophilia were exclusion criteria. The Odds Ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the risk of pregnancy loss.
Results: The combination of non-O group and thrombophilia was present in 25 (16%) cases and 51 (7.2%) controls (OR 3.27; CI 1.85 to 5.76); women with both O blood group and thrombophilia were 10 (6.4%) among cases in comparison to 34 (4.8%) controls (OR 1.96; CI 0.91 to 4.22). Finally, non-O group without thrombophilia was present in 73 (46.8%) cases and 307 (43.1%) controls (OR 1.59; CI 1.07 to 2.36).
Conclusions: Our results underline a significant higher prevalence in women with abortion of either non-O blood type or thrombophilia. The combination of both (e.g. non-O blood type and thrombophilia) further increases this risk. Larger studies are warranted to confirm our results and to clarify the clinical implications of our findings.
To cite this abstract in AMA style:Poretto A, Spiezia L, Borella E, Turatti G, Marobin M, Campello E, Simioni P. ABO Blood Groups and Inherited Thrombophilia in Women with Abortion [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/abo-blood-groups-and-inherited-thrombophilia-in-women-with-abortion/. Accessed March 3, 2021.
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