Abstract Number: PB0773
Meeting: ISTH 2020 Congress
Background: Vitamin K (VK) is a fat-soluble vitamin that acts as a cofactor in the coagulation process, and factor (F)II, FVII, FIX, FX, and proteins anticoagulants (S, C, and Z) are functional. The acquired deficiency of VK-dependent factors is a heterogeneous entity in its causes and clinical hemorrhagic manifestations. The medical challenge is to approach the patient with hemorrhagic or asymptomatic clinic, with prolongation of PT without clear cause.
Aims: Describe the demographic and clinical characteristics of patients with acquired deficiency of VK-dependent coagulation factors.
Methods: Descriptive study, serial type of cases, patients over 18 years of age, with acquired deficiency of VK-dependent factors, January 2008 to December 2018. Patients with other specific deficiencies of coagulation factors were excluded.
Qualitative variables were described by absolute and relative frequencies and quantitative variables by central trend and dispersion measures by distribution.
Results: We describe 7 patients with acquired impairment of dependent factors of VK. The median age was 41 years. The average hospital stay value was 15 days with 11-day IQR.
The predominant clinical manifestation was mucosal bleeding in 42.8% of cases. The median PT was 26.9 seconds and the median INR was 2.4 with IQR of 17.7.
Etiology in 3 cases due to administration of auto formulated warfarin. 1 for Multivitamin intake (in this case without the conditions of registration by the country´s health agency), 2 for prolonged fasting and concomitant use of antibiotics and one patient with bariatric surgery who suspended micronutrients. Treatment was in 4 cases vitamin K, one patient with plasma transfusion and one patient received recombinant factor VII A.
Conclusions: The acquired deficiency of VK-dependent coagulation factors is a difficult diagnosis due to its low frequency. Clinical presentation varies from asymptomatic to severe hemorrhagic complications. The cause must always be sought; the search for psychiatric disorders, or unlawful actions must be deepened.
To cite this abstract in AMA style:Daza J, Casas C, Solano MH. Acquired Deficiency of Dependent Coagulation Factors of Vitamin K, at the Teaching Center: Experience In 10 Years [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/acquired-deficiency-of-dependent-coagulation-factors-of-vitamin-k-at-the-teaching-center-experience-in-10-years/. Accessed January 28, 2022.
« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/acquired-deficiency-of-dependent-coagulation-factors-of-vitamin-k-at-the-teaching-center-experience-in-10-years/