Abstract Number: PB0739
Meeting: ISTH 2021 Congress
Background: Acquired isolated factor VII (FVII) deficiency is a rare bleeding disorder and it can be associated with an oncological disease.
Aims: To investigate the acquired isolated FVII deficiency associated with malignancy.
Methods: We analyzed FVII deficiency found in the tests performed in our hospital from 2018 to 2020. Inclusion criteria were isolated FVII defect of less than 55% of normal, normal level of other vitamin K-dependent clotting factors, no history of liver disease and negative coagulation pattern in the family. All these patients had at least 2 samples with a prolonged PT and a normal PT mixing study.
Results: 43 patients had an isolated FVII deficiency and met the inclusion criteria. 6 had an infection, 21 patients had a recent history of malignancy and 16 had no relation with any disease.
The 21 oncological patients had a normal prothrombin time (PT) before the diagnosis of the malignant disease and none of them had bleeding history. 12 of these patients died during the first year after the diagnosis of the FVII deficiency.
Median age was 65 ( range 16-91), 16 were men and 5 women. The mean level of FVII was 42% ( range 21,4-51% )
The most frequent tumor involved was genitourinary and the histological type, adenocarcinoma.
Only 2 out of 21 patients had bleeding symptoms and in both cases was a moderate hematuria associated with bladder tumor.
|CLEAR CELL CARCINOMA||1|
|NOT HISTOLOGICAL RESULT||3|
Conclusions: Acquired isolated FVII deficiency is a rare defect, which appears to be associated with several conditions, especially sepsis and tumors. This indicates the need for a careful investigation of even a mild prolongation of prothrombin time, especially in oncological patients.
To cite this abstract in AMA style:García-León N, Calderón-López MT, Gómez-Arevalillo Hidalgo S, Martín-Serrano Martín P, Matilla-García A. Acquired Isolated FVII Deficiency in Oncological Patients [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/acquired-isolated-fvii-deficiency-in-oncological-patients/. Accessed December 8, 2021.
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