Abstract Number: PB0462
Meeting: ISTH 2020 Congress
Background: The diagnosis of thrombosis is heavily dependent on D-dimers determination. Evaluation of D-dimers is one of the most used diagnostic tools for assessment of thrombogenic state, but their all-embracing meaning is hindering their diagnostic value. The determination of active thrombin might be an additional independent important value in the D-dimers assay.
Aims: Aim of this study was to determinate the presence of active thrombin bound to D-dimers in various pathological condition.
Methods: Patients samples were obtained in accordance with The Ethic committees of participating institutions (IHBT, Prague and MUH, Prague). Qualifying criterions were elevated D-dimers and consent to the study. From 98 patients, medical history and treatment protocols were acquired from 83 of them.
Results: The presence of active thrombin bound to D-dimers was shown to be linked with thrombotic diagnosis – more than 60 % cases of thrombogenic states had active thrombin bound to D-dimers. More than 33 % of other pathological conditions had active thrombin bound to D-dimers – out of them 70 % was linked with complications or death.
Conclusions: The presence of active thrombin bound to circulating D-dimers has been proposed to help to differentiate between thrombogenic state and other pathological conditions linked with elevated D-dimers. Detection of active thrombin bound to D-dimers might be used as another qualitative step in assessment of the patient’s condition and prognosis.
Acknowledgement: Authors would like to highlight the contribution of M Maly, J Suttnar, O Kucerka, J Louzil, P Salaj, M Zemanova, E Ceznerova, K Svobodova and I Hrachovinova to the acquisition of samples.
This work was supported by the ERDF and the state budget of the Czech Republic (project AIIHHP: CZ.02.1.01/0.0/0.0/16_025/0007428, OP RDE, Ministry of Education, Youth and Sports), by the Ministry of Health, Czech Republic (project 00023736; grant NV18-08-00149) and by ERDF OPPK (CZ.2.16/3.1.00/24001).
To cite this abstract in AMA style:Stikarova J, Dyr J. Active Thrombin and its Value: New Approach to Diagnosis of Thrombosis? [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/active-thrombin-and-its-value-new-approach-to-diagnosis-of-thrombosis/. Accessed January 27, 2022.
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