Abstract Number: VPB0682
Meeting: ISTH 2022 Congress
Theme: Hemophilia and Rare Bleeding Disorders » Hemophilia - Clinical
Background: Given the disparate access to coagulation factor concentrates (CFC) in resource-constrained countries and individual preferences, on-demand therapy remains a treatment option for the management of haemophilia. Non-adherence can delay desired treatment outcomes There is a dearth of evidence on adherence to on-demand therapy among PWH in sub–Saharan Africa
Aims: To evaluate self-reported/ parent-reported adherence to on-demand therapy among PWH and establish the associations between adherence and presence of target joints and annualized bleed rate
Methods: A cross-sectional survey of 55 participants on episodic treatment recruited during outpatient appointments in 5 haemophilia treatment centers (HTC) across Nigeria using the validated Haemophilia Regimen Treatment Adherence Scale- Prophylaxis (VERITAS -PRN), 24 questions on six (four-item) subscales (treat, time, dose, plan, remember, and communicate). The options of VERITAS -PRN were represented in 5 Likert scale and possible subscale ranged from 4 points (most adherent)to 20 points (least adherent) and possible total score ranging from 24 (most adherent) to 120 (least adherent ) the cut off for overall adherence put at >61 to indicate non-adherence.
Results: Of the 55 participants, 94.1% both had haemophilia A and target joints. The majority, 51(92.7%) had scores indicating non adherence. The mean age of non-adherent and adherent participants were 19(13.9) years and 24(13.23) years, respectively. For the non-adherent, the overall mean score was 68.05(8.54) Subscale scores range from 9.38 (treat) to 15.00 (remember) There was a significant difference in the overall adherence scores and subscale scores between adherent and non-adherent participants with p value < 0.05 . There was a significant association between mean log of the number of target joints and the communicating subscale for the non-adherent group, r-0.61 p value < 0.05.
Conclusion(s): Adherence to on-demand therapy is generally poor. Most were non intentionally skipping their doses. The association between the communication subscale and the number of target joints was significant.
To cite this abstract in AMA style:
Nwagha T, Okoye H, Yuguda S, Udo C, Gwarzo D, Ogunfemi M, Osuji N. Adherence To On Demand Treatment Regimen And Bleeding Outcome (A Multicenter Nigerian Study) [abstract]. https://abstracts.isth.org/abstract/adherence-to-on-demand-treatment-regimen-and-bleeding-outcome-a-multicenter-nigerian-study/. Accessed April 18, 2024.« Back to ISTH 2022 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/adherence-to-on-demand-treatment-regimen-and-bleeding-outcome-a-multicenter-nigerian-study/