Abstract Number: VPB0633
Meeting: ISTH 2022 Congress
Background: Dysregulation of certain adipokines can promote pathogenic conditions associated with insulin resistance. The contributions of individual adipokines to the pathophysiological features of cardiometabolic diseases remain controversial.
Aims: To evaluate the association of adipokines and insulin resistance in young individuals with various metabolic phenotypes.
Methods: A cross-sectional study included 251 patients: group 1 – healthy metabolic profile with normal body weight (n=62); group 2 – unhealthy metabolic profile with normal body weight (n=57); group 3 – healthy metabolic profile and obesity (n=16); group 4 – unhealthy metabolic profile and obesity (n=116). Statistical significance was defined as p < 0.05.
Results: Individuals with unhealthy metabolic profile and obesity had the highest serum levels of leptin, plasminogen activator inhibitor-1 (PAI-1) and angiotensin II and the lowest serum levels of adiponectin. Overall, there was a significant relationship between the concentration of PAI-1 and insulin (Spearman r=0.345, p=0.01), PAI-1 and HOMA-IR index (Spearman r=0.251, p=0.06) among metabolically unhealthy obese individuals. The most significant linear correlations among metabolically unhealthy individuals with normal body weight were obtained between PAI-1 and angiotensin II (Spearman r=0.484, p=0.03), PAI-1 and endothelin-1 (Spearman r= – 0.462, p=0.04).
Conclusion(s): Understanding of the diverse effects of distinct adipokines and their interactions is still incomplete. Unraveling the pathophysiological roles of adipokines in young individuals with various metabolic phenotypes likely will result in a new personalized therapy strategy.
To cite this abstract in AMA style:Chulkov V, Vereina N, Gavrilova E, Lenets E, Pankova E, Martynov S, Sinitsin S. Adipokines and insulin resistance in young individuals with various metabolic phenotypes [abstract]. https://abstracts.isth.org/abstract/adipokines-and-insulin-resistance-in-young-individuals-with-various-metabolic-phenotypes/. Accessed September 26, 2022.
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