Abstract Number: PB1570
Meeting: ISTH 2020 Congress
Theme: Platelet Disorders and von Willebrand Disease » VWF and von Willebrand Factor Disorders - Clinical Conditions
Background: Adolescent metrorrhagia most often results from hormonal dysfunction, 10 to 20% related to a constitutional abnormality of hemostasis including 70% of Willebrand Diseases
As no gynecological etiology is found in half of the cases, the possibility of abnormalities of hemostasis is often raised. By enabling targeted treatment, the identification of a hemostasis disorder contributes to improving the quality of life of women
Menorrhagia can cause anemia, fatigue and absenteeism from school or work
Aims: Hemostasis disorders should always be investigated in case of adolescent meno-metrorrhagia
Methods: We proceeded to a meticulous interrogation, personal and family history of bleeding, the realization of a blood assessment, a hemogram, a prothrombin time, an aPTT, fibrinogen and evaluation of the platelet function According to the first results , additional examinations were carried out; measurement of FvW activity and antigen complemented by measurement of factor VIII. Particular account was taken of the blood group, and the measurement of the FvW was made on D5-D7 of the menstrual cycle
Results: This is a prospective study from September 2016 to September 2019 9 cases of von willebrand disease were diagnosed with hemorrhagic symptoms like menorrhagia The average age is 17 years, 4 patients in groups O positive, two A positive and three group B (2 rhesus positive and 1 rhesus negative), the first menstruation was hemorrhagic with an abnormal duration in the 9 patients(100%) there were 3 cases of von willebrand disease typeIIB and 6cases of type 3.The prevalence of the decline in FvW in menorrhagia is 10 to 20% (Kirtava A et al,) and that 50 to 75% of women with von Willebrand disease have menorrhagia (Woo YL, and al).
Conclusions: Coagulopathies constitute 20% of cases of pubertal metrorrhagia. It is imperative to look for hemostasis disorders in the case of adolescent menometrorrhagia
To cite this abstract in AMA style:
Ouarhlent Y, Makhloufi MR. Adolescent Menorrhagia and Von Willebrand Disease [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/adolescent-menorrhagia-and-von-willebrand-disease/. Accessed January 26, 2022.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/adolescent-menorrhagia-and-von-willebrand-disease/