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Advanced Principles of Prevention and Treatment of Preeclampsia in Women with Antiphospholipid Syndrome (APS) and MTHFR C677T Mutation

1Clinical Diagnostic Center for Thrombosis and Hemostasis, Tbilisi, Georgia, 2Tbilisi State Medical University, Department of Obstetric and Gynecology, Tbilisi, Georgia, 3Tbilisi State Medical University, Perinatal Centre, Tbilisi, Georgia, 4Tbilisi State Medical University, Internal Medicine, Tbilisi, Georgia

Abstract Number: PB0787

Meeting: ISTH 2020 Congress

Theme: Hemophilia and Rare Bleeding Disorders » Acquired Hemorrhagic Coagulation Disorders

Background: Improve the principles of prevention and treatment of preeclampsia in women with APS and genetic forms of thrombophilia.

Aims: Improve the principles of prevention and treatment of preeclampsia in women with APS and genetic forms of thrombophilia.

Methods: 55 women were studied, which were divided into two groups: group I consisted of 23 women – pregnant women who had episodes of preeclampsia in previous pregnancies (in anamnesis), group II included primigravidas with preeclampsia during the current pregnancy. All pregnant women were diagnosed with lupus anticoagulant and high titers of anticardiolipin antibodies (Anticardiolipin IgG).

Results: Pathogenetically based prevention using low-molecular-weight heparin (bemiparin), folic acid, B vitamins and antioxidants in patients with preeclampsia caused by APS and genetic form of thrombophilia from early pregnancy and throughout pregnancy allowed to improve the gestational period and prolong pregnancy, to improve perinatal outcomes in pregnant women. It should be noted that significantly better outcomes occurred in patients who got therapy already at the pregravidar preparation stage and received low-molecular-weight heparin, folic acid, B vitamins and antioxidants throughout pregnancy.

Conclusions: Timely diagnosis, pathogenetic prevention and differentiated therapy allow not only to prevent the development of obstetric complications, but also to reduce maternal and perinatal morbidity and mortality.

To cite this abstract in AMA style:

Jangidze M, Kintraia N, Zhorzholiani P, Saralidze T, Metskhvarishvili N, Rizvadze M. Advanced Principles of Prevention and Treatment of Preeclampsia in Women with Antiphospholipid Syndrome (APS) and MTHFR C677T Mutation [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/advanced-principles-of-prevention-and-treatment-of-preeclampsia-in-women-with-antiphospholipid-syndrome-aps-and-mthfr-c677t-mutation/. Accessed September 27, 2023.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/advanced-principles-of-prevention-and-treatment-of-preeclampsia-in-women-with-antiphospholipid-syndrome-aps-and-mthfr-c677t-mutation/