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Alterations in the coagulation profile and mortality due to covid-19 during the first and second wave in peruvians: A retrospective cohort in a national reference center.

1Ricardo Palma University, Lima-Peru., Lima, Lima, Peru, 2Clinical Research Institute “Fausto Garmendia Lorena". National University "Mayor de San Marcos", Lima-Peru., Lima, Lima, Peru, 3Nephrology Service. National Hospital "Dos de Mayo", Lima-Peru, Lima, Lima, Peru, 4Research Institute in Biomedical Sciences (INICIB). Ricardo Palma University, Lima-Peru., Lima, Lima, Peru

Abstract Number: VPB0130

Meeting: ISTH 2022 Congress

Theme: COVID and Coagulation » COVID and Coagulation, Clinical

Background: Changes in the coagulation profile have been associated with adverse clinical outcomes in patients with COVID-19. It is relevant to evaluate the changes in the coagulation profile and its impact on mortality from COVID-19 during the first and second waves in Peru.

Aims: To evaluate the alterations and impact of the coagulation profile on mortality from COVID-19 during the first and second waves in Peruvians.

Methods: Retrospective cohort carried out at the “Dos de Mayo” National Hospital, Lima-Peru during the years 2020 and 2021. Peruvians over 18 years of age were included, excluding those with congenital hemostasis disorders, pneumonia caused by other agents and chronic users of anticoagulants. SARS-COV2 pneumonia was defined as infiltrate in lung TEM + positive RT-PCR. Alterations in coagulation parameters were determined by prolonged prothrombin time (PT>14s) and/or prolonged activated thromboplastin time (APTT>35s) and/or fibrinogen < 200 mg/dL and/or fibrinogen >400 mg/dL. dL. The sample was consecutive, reaching a sample of 300 patients from the first and 300 from the second wave. Data was collected and entered into a database and sent for analysis after quality control. Were presented summary measures for the qualitative and quantitative variables. A logistic regression equation was modeled to estimate the adjusted OR of the different coagulation parameters altered. The data were processed RStudio version 1.3.1093.

Results: A total of 600 patients were included. Male was the most frequent sex during the two periods. Figure 1 shows the baseline characteristics. Fibrinogen < 200mg/dL during the first wave was associated with a lower risk of death (OR: 0.07; 95%-CI: 0.01, 0.90). Table 2 shows the results of the multivariate analysis.

Conclusion(s): Apparently the changes in the coagulation profile caused by COVID-19 in Peruvians during the first and second waves were not associated with higher mortality. Low fibrinogen seemed to offer protection during the first wave.

Table

Table 1. Baseline characteristics of Peruvians with COVID-19 pneumonia during the first and second waves

Table

Table 2. Multivariate analysis between coagulation profile alterations and COVID-19 mortality in Peruvians

To cite this abstract in AMA style:

Pichardo-Rodriguez R, Peña-Oscuvilca W, cordova-Cueva L, DE LA CRUZ-VARGAS J, Ruiz-Franco O, Garmendia-Lorena F. Alterations in the coagulation profile and mortality due to covid-19 during the first and second wave in peruvians: A retrospective cohort in a national reference center. [abstract]. https://abstracts.isth.org/abstract/alterations-in-the-coagulation-profile-and-mortality-due-to-covid-19-during-the-first-and-second-wave-in-peruvians-a-retrospective-cohort-in-a-national-reference-center/. Accessed September 21, 2023.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/alterations-in-the-coagulation-profile-and-mortality-due-to-covid-19-during-the-first-and-second-wave-in-peruvians-a-retrospective-cohort-in-a-national-reference-center/