Background: In SARS-COV2 infection, little is known about the changes in the coagulation profile that occur at admission that could predict future events such as bleeding or thrombosis.

Aims: To establish the alterations in the coagulation profile of Peruvians with SARS-COV2 pneumonia at the time of their admission to a national referral hospital.

Methods: A cross-sectional, retrospective study was carried out in Peruvians diagnosed with SARS-COV2 pneumonia admitted to the “Dos de Mayo” National Hospital, between June and November 2020. Pneumonia due to other agents were excluded.
SARS-COV2 pneumonia was defined as: pulmonary TEM infiltrate + positive RT-PCR or positive rapid test (IgG and IgM). Alterations in the coagulation profile were determined by: prolonged prothrombin time (PT> 14 seconds) and / or prolonged activated thromboplastin time (APTT> 35 seconds) and / or fibrinogen <200 mg / dL. Additional variables such as age and sex were recorded.
The sample was selected consecutively. The data were collected and entered into a database and sent for analysis after quality control.
Frequencies and percentages were presented for the qualitative variables and summary measures for the quantitative variables. The data were processed RStudio version 1.3.1093.

Results: A total of 100 patients were included. Male sex was the most frequent (63%) and the mean age was 54.74 ± 16 years. Seventy-one percent had PT prolongation and 36% had APTT prolongation. Only 5% had fibrinogen <200mg / dL.

Conclusions: There is a high prevalence of alterations in the coagulation profile, predominantly prolonged PT. It is relevant to evaluate in prospective studies whether these changes can predict future bleeding or thrombotic events.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/alterations-of-the-coagulation-profile-in-peruvians-admitted-for-pneumonia-due-to-sars-cov2-cross-sectional-study/