Abstract Number: PO162
Meeting: ISTH 2021 Congress
Background: Immune thrombocytopenia (ITP)can be observed in lymphoproliferative disorders, most commonly chronic lymphocytic leukemia (CLL), the minority of cases are reported in patients with Hodgkin lymphoma (HL). Some studies estimated that the prevalence of ITP with HD is 0.2% to 1%. And the prognostic significance of its presence is unclear.
Aims: Our report broadens the knowledge about the clinical and therapeutic management of patients with Hodgkin lymphoma.
Methods: A 31-year-old female five years ago accepted cervical lymph node biopsy, and diagnosed with classical Hodgkin lymphoma with an interfollicular pattern. She just received 2 cycles of ABVD, and later refused regular treatment and reexamination. About 57 months after her initial treatment, she had multiple hospitalized for gum bleeding, petechiae and epistaxis with platelets of 5,000/µL. A subsequent bone marrow aspiration showed increased immature megakaryocytes. After a week, she was referred to our hospital with complaint of epistaxis. CT showed extensive cervical lymphadenopathy. She was treated by oral prednisolone 45 mg/day and platelet transfusion. A repeat cervical lymph node biopsy a week later was consistent with lymphocyte-rich classical Hodgkin lymphoma (LRCHL). She subsequently underwent chemotherapy in combination with 2 cycles of ABVD therapy. In January 2021, the patient achieved a significant increase in platelet count and decrease in lymph nodes’ size. We will schedule a detailed follow-up, in order to monitor the immune dysregulation.
Results: This report documents a significant recurrence of lymphoma in the presence of ITP in HL patient. Anti-lymphoma therapy could achieve platelet count recovery.
Conclusions: In this case, the patient’s ITP is regarded as paraneoplastic syndrome. Only proper combination chemotherapy treatment of the underlying lymphoma can successfully control the ITP, and curtail unnecessary transfusions to a patient.
To cite this abstract in AMA style:Yang M, Zhou Z. Anti-lymphoma Therapy Improves Thrombocytopenia in a Young Patient with Hodgkin Lymphoma: A Case Report [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/anti-lymphoma-therapy-improves-thrombocytopenia-in-a-young-patient-with-hodgkin-lymphoma-a-case-report/. Accessed February 27, 2024.
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