Abstract Number: PB0029
Meeting: ISTH 2020 Congress
Theme: Arterial Thromboembolism » Atherosclerosis
Background: Currently, there is a large amount of literature data indicating the violation of antioxidant balance and the development of oxidative stress in various diseases. It is known that in certain forms of cardiovascular disease, the activity of antioxidant enzymes, such as superoxide dismutase, increases, which plays a key role in reducing oxidative stress in vivo, that is, it is a protective factor. Impaired function of this enzyme leads to an increase in the number of free radicals in the cell. The article was prepared as part of a study supported by a grant from the Russian Foundation for Basic Research, project No. 18-00-00814-COMFI (18-00-00478).
Aims: To study the polymorphism of the SOD1 G7958A and SOD2 Ala16Val gene in the Nenets population.
Methods: The object of study is the indigenous population of the island village of Varnek (n = 44). The age of the sample is 25 [17.3; 51.6] years.
The determination of gene polymorphism was carried out during molecular genetic analysis using the polymerase chain reaction method using allele-specific primers with agarose gel electrophoresis detection.
Results: In our study, the polymorphism of the SOD1 G7958A and SOD2 Ala16Val genes was analyzed in a sample of the indigenous ethnic group (n = 44).
In this population, the GG genotype of the SOD1 G7958A gene is found in 79.5% of the sample, GA – 18.2%, AA – 2.3%. The Ala / Ala genotype of the SOD2 gene is found in 12%, Ala / Val – 31.2%, Val / Val – 56.8%.
Conclusions: Peculiarities of the prevalence of SOD enzyme polymorphism in the island population of Nenets were revealed.
To cite this abstract in AMA style:
Vorobyeva N, Belova N, Vorobyeva A, Nemanova S. Antioxidant Defense Gene Polymorphism in the Nenets Population [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/antioxidant-defense-gene-polymorphism-in-the-nenets-population/. Accessed November 29, 2023.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/antioxidant-defense-gene-polymorphism-in-the-nenets-population/