Abstract Number: PB0173
Meeting: ISTH 2021 Congress
Background: Severely ill patients with SARS-CoV-2 have at increased risk of venous thromboembolism (VTE). However, the VTE risk in patients with mild to moderate COVID-19 remains uncertain.
Aims: To assess the risk of VTE in patients with mild to moderate COVID-19 patients versus similar patients without COVID-19 and to define VTE risk factors in COVID-19 patients.
Methods: A prospective cohort of patients presented to ED for acute dyspnea or chest pain and having confirmed or probable mild to moderate COVID-19 was retrospectively compared to a prospective cohort of similar ED patients using propensity score matching. Patients having diagnostic testing for suspected PE and for whom PE was initially ruled-out were included. Univariate and multivariate analysis of possible VTE risk factors were performed in the COVID-19 patients. The main outcome was the rate of symptomatic VTE, deep venous thrombosis or pulmonary embolism, within the 28 days after ED presentation.
Results: A total of 2292 patients were included in the COVID-19 cohort and 1539 in the comparison cohort. After adjustment, the 28-day rate of symptomatic VTE was 1.87% (95%CI: 0.95 to 3.24) in the COVID-19 cohort and 0.18% (95%CI: 0.01 to 1.63) in the comparison cohort. The absolute difference was +1.69% (95%CI: 0.88 to 2.51, p< 0.001), +3.45% (95%CI: 1.80 to 5.11) in hospitalized patients and +0.50% (95%CI: 0.22 to 1.23) in patients treated at home. In the COVID-19 cohort, hospitalization and age > 65 years were independent risk factors of symptomatic VTE but not the lack of thromboprophylaxis.
Conclusions: Patients with mild-to-moderate COVID-19 presenting to ED had a higher risk of subsequent VTE than similar patients, especially if they are older than 65 years and required hospitalization.
To cite this abstract in AMA style:Douillet D, Riou J, Penaloza A, Moumneh T, Soulié C, Savary D, Morin F, Mahieu R, Roy P-. Are Mild or Moderate COVID-19 Patients at Higher Risk of VTE? A Comparison of Two Prospective European Cohorts in Emergency Departments [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/are-mild-or-moderate-covid-19-patients-at-higher-risk-of-vte-a-comparison-of-two-prospective-european-cohorts-in-emergency-departments/. Accessed August 9, 2022.
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