Abstract Number: PB0417
Meeting: ISTH 2021 Congress
Background: Plasminogen activator inhibitor-1 (PAI-1) as the main regulator of fibrinolysis, has been shown to be elevated in metabolic syndrome and generally is correlated with the number of components of metabolic syndrome. However, it is important to investigate its relationship to cardiovascular biomarkers in various metabolic phenotypes.
Aims: To evaluate the association of adipokines and fibrinolytic markers in young adults with normal body weight and obesity.
Methods: A cross-sectional study included 251 patients: group 1 – healthy metabolic profile with normal body weight (n=62); group 2 – unhealthy metabolic profile with normal body weight (n=57); group 3 – healthy metabolic profile and obesity (n=16); group 4 – unhealthy metabolic profile and obesity (n=116). Statistical significance was defined as p<0.05.
Results: The concentration of serum leptin (ng/ml) was higher in group 4 (37.9 [13.0-63.4]) vs group 1 (10.0 [5.1-15.5]); group 2 (9.5 [5.5-21.5]); group 3 (25.7 [4.7-37.2]), p4-1.2.3 <0.05. The lowest concentrations of adiponectin (μg/ml) were found in patients with obesity – group 3 (7.9 [4.9-10.2]) and group 4 (7.9 [5.2-12.4]) compare to group 1 (9.1 [7.5-12.2] and group 2 8.7 [7.2-10.5], p3.4-1.2<0.05). Individuals in group 4 had higher concentrations of PAI-1 (ng/ml): 464.5 [285.1-628.5] vs 308.2 [211.7-415.7] – group 1; 342.3 [222.2-490.0] – group 2; 371.0 [273.1-621.0] – group 3, p4-1<0.001. Overall, there was a significant relationship between the concentration of PAI-1 and levels of systolic (Spearman r=0.337, p=0.04) and diastolic blood pressure (r=0.314, p=0.022) in group 1. The most significant linear correlations among metabolically unhealthy obese individuals were obtained between diastolic blood pressure and fibrinogen levels (r=0.346, p<0.001), as well as body mass index and serum leptin (r=0.521, p<0.001).
Conclusions: In the present study, we found that young individuals with unhealthy metabolic profile and obesity had significantly higher levels of leptin, fibrinogen, PAI-1 and lower levels of adiponectin than their counterparts with normal body weight.
To cite this abstract in AMA style:Chulkov V, Gavrilova E, Chulkov V, Vereina N, Sinitsin S, Martynov S, Tkachenko P, Lenets E. Assessment of Сardiometabolic Biomarkers in Young Adults with Normal Body Weight and Obesity [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/assessment-of-%d1%81ardiometabolic-biomarkers-in-young-adults-with-normal-body-weight-and-obesity/. Accessed September 21, 2023.
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