Abstract Number: PB0599
Meeting: ISTH 2020 Congress
Background: Increasing accreditation requirements challenge the laboratory’s time, resources and expertise. ExpertCor is a range of frozen plasma sets, spanning the full measuring range of the parameter of interest prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, D-Dimer, unfractionated heparin (UFH) or low molecular weight heparin (LMWH). The ExpertCor plasma sets can be used to supplement local patient samples, to ensure assay comparability as part of system to system comparisons, lab to lab comparisons or lot to lot conversions.
Aims: We evaluated the ExpertCor plasma sets on various Stago analyzers to assess suitability for assay comparability purposes.
Methods: Each plasma set was assayed on the STA®-R Max, STA® Compact Max and the STA® Satellite.
Each sample of ExpertCor Routine was assayed for PT seconds, APTT and Fibrinogen using STA®-Neoplastin® CI Plus, STA®-PTT-Automate and STA®-Liquid Fib. 5 samples of the set were also assayed for PT in INR.
The ExpertCor DDi, ExpertCor UFH/LMWH sets were assayed for DDi and anti-Xa activity using the STA®-Liatest® DDi and STA®-Liquid Anti-Xa, respectively.
All analyzers and reagents are from Stago (Asnières-sur-Seine, France).
For each parameter, linear correlation was used to compare analyzers two by two.
Results: A summary of the computed linear regressions obtained is displayed in the table.
On the 5 INR samples, the delta in INR was lower than 0.6; the higher differences being observed on the sample with INR level around 7.
|STA Compact Max vs STA R Max||STA Satellite vs STA Compact Max||STA Satellite vs STA R Max|
|PT (sec)||y = 1.0494x – 0.9632 r = 0.998||y = 09376x + 0.7962 r = 0.999||y = 0.9859x – 0.1629 r = 0.999|
|APTT (sec)||y = 1.2254x – 3.3478 r = 0.998||y = 1.0488x – 2.1695 r = 0.998||y = 1.2885x – 5.8633 r = 0.998|
|Fibrinogen (g/L)||y = 1.1207x – 0.0754 r = 0.996||y = 0.9725x – 0.0336 r = 0.996||y = 1.0965x – 0.1208 r = 0.999|
|DDi (µg/mL)||y = 0.9788x + 0.077 r = 1.000||y = 0.96x + 0.0392 r = 0.994||y = 0.9406x + 0.107 r = 0.995|
|Anti-Xa (IU/mL)||y = 0.9965x – 0.0082 r = 0.997||y = 0.9675x + 0.0007 r = 0.993||y = 0.9703x – 0.0122 r = 0.996|
[Summary of linear correlations of Stago analyzers using the ExpertCor sets of plasma (equation and Pearson correlation coefficient (r)).]
Conclusions: Our correlation results indicate that ExpertCor it is a convenient tool for use in verification studies and highlights the excellent system comparability within the Stago line of analyzers.
Moreover, while saving time to seek and collect a large number of plasma samples locally, ExpertCor can help laboratories gain operational efficiency.
To cite this abstract in AMA style:Yirga D, Baudier J-, Carlo A, Bourgeat P. Assessment of ExpertCor, a New Set of Frozen Plasmas for Assay Comparability Studies [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/assessment-of-expertcor-a-new-set-of-frozen-plasmas-for-assay-comparability-studies/. Accessed October 1, 2023.
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