Abstract Number: PB2188
Meeting: ISTH 2020 Congress
Background: Hypofibrinolysis has been linked to the development of thrombosis, both venous and arterial. Previous studies have suggested a variable association of the fibrinolysis markers with thrombosis in different settings. There is a paucity of literature from India regarding the role of various fibrinolytic parameters in deep venous thrombosis (DVT).
Aims: To assess the fibrinolytic parameters in patients with DVT.
Methods: A total of 52 patients and 52 controls were included in the study. The quantitative determination of plasminogen activator inhibitor-1 (PAI-1), plasminogen, thrombin activable fibrinolysis inhibitor (TAFI), α2-antiplasmin and tissue plasminogen activator (t-PA) was performed by enzyme-linked immunosorbent assay. Thrombophilic parameters including protein C, protein S, anti-thrombin III, antiphospholipid antibodies and Factor V Leiden mutation (FVL) mutation were assessed. The association of continuous variables between cases and controls was compared using student t-test or Mann-Whitney U test. The categorical variables were compared using Chi-square test.
Results: The patient group comprised of 27 males and 25 females and the control group had 35 males and 17 females. DVT was unprovoked in 61.5% cases and idiopathic in 40.38% cases. TAFI, plasminogen and t-PA levels were significantly higher in cases than controls. PAI-1 was significantly lower in cases than controls. α2-AP levels were statistically insignificant (Table1). TAFI, plasminogen and t- PA levels were significantly higher in unprovoked and idiopathic DVT cases than controls. The most common inherited thrombophilic risk factor was FVL mutation followed by protein C and anti-thrombin III deficiency.
Conclusions: Plasma TAFI, plasminogen and t-PA levels were significantly higher in cases than controls suggesting a positive association with DVT. A similar trend was also observed in unprovoked and idiopathic DVT cases.
|Fibrinolytic marker||Cases (median)||Controls (median)||Cases (range)||Controls (range)||Cases (SD)||Controls (SD)||p-value|
|α-1 anti-plasmin (µg/ml)||78.92||70.347||6.76-108.95||42-140.95||25.4237||19.4941||0.678|
|Plasminogen (mg/dl)||2.807||2.207||1.6992-6.1600||0.312-4.1907||0.9734||0.7316||0.678 <0.001|
[Comparison of fibrinolytic parameters between cases and controls]
To cite this abstract in AMA style:Sharma S, Uppal V, Kumar N, Renee H, Ahluwalia J, Das R, Varma N, Malhotra P. Assessment of Fibrinolysis Markers in Patients with Lower Limb Deep Venous Thrombosis: A Prospective Case-control Study [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/assessment-of-fibrinolysis-markers-in-patients-with-lower-limb-deep-venous-thrombosis-a-prospective-case-control-study/. Accessed January 21, 2022.
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