Abstract Number: PB1408
Meeting: ISTH 2020 Congress
Background: An analysis of the blood coagulation system in patients with cardiovascular diseases, including during antithrombotic and antiplatelet therapy, is an actual clinical task.
Aims: The aim of the study was to quantify the process of thrombus formation under conditions of blood flow by T-TAS technology in patients with chronic coronary syndrome (CCS) using antiplatelet therapy.
Methods: 140 measurements were performed using T-TAS on two type microchip flow-chamber system in a group of 54 patients with CCS treated 100 mg acetylsalicylic acid and 16 healthy controls: collagen-coated microchip PL and collagen+tissue factor-coated microchip AR for a functional assessment of the contribution and activation of platelets and plasma coagulation factors in the process of thrombus formation.
Results: The following dates (Me(Q1-Q3)) were obtained in CCS patients and controls for indicators measured on the AR microchip: AR T10=7,92(5,32-8,88) sec; AR T80=10,69(8,69-12,36) sec; AR AUC=1659,3(1584,1-1795,6) versus AR T10=8,54(8,0-9,09) sec; AR T80=10,64(10,0-11,29) sec; AR AUC=1647,5(1598,6-1696,3) and for PL microchip: PL T10=3,32(2,40-4,54) sec; PL AUC=126,60(69,4-233,8) versus PL T10=3,23(3,16-4,37) sec; PL AUC=256,65(17,4-301,9), respectively. The significant twofold decrease in PL AUC (p=0,02) should be noted, reflecting a decrease in the overall functional activity of platelets in CCS patients compared with healthy individuals due to the use of antiplatelet agents. However, 10 patients were aspirin-resistant and their T-TAS PL indicators were higher than in the controls and other CCS patients: PL Т10=2,4(1,9-2,7) sec; PL AUC=344,5(292,8-388,0) versus PL T10=3,23(3,16-4,37) sec; PL AUC=256,65(17,4-301,9) and PL Т10=4,3(3,2-5,0) sec; PL AUC=120,1(88,6-159,1), respectively (р< 0,05).
Conclusions: The value of PL AUC measured by T-TAS is a potential parameter for evaluation of the antiplatelet therapy effectiveness in patients with chronic coronary syndrome.
To cite this abstract in AMA style:Sirotkina O, Nazarova I, Melnichnikova O, Panov A, Vavilova T. Assessment of the Hemostatic System by Total Thrombus-formation Analysis System (T-TAS) in Patients with Chronic Coronary Syndromes [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/assessment-of-the-hemostatic-system-by-total-thrombus-formation-analysis-system-t-tas-in-patients-with-chronic-coronary-syndromes/. Accessed January 27, 2022.
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