Abstract Number: PB1256
Meeting: ISTH 2020 Congress
Background: Vitamin K deficiency bleeding(VKDB) has been classified by age of onset into early (< 24 hours), classical (days 1-7) and late (1 week to 6 months), and by etiology into idiopathic and secondary in 1999 by the Pediatric and Perinatal Subcommittee of ISTH. Limited data are available on the relative frequencies of early, classic, and late vitamin k deficiency bleeding and exact level of vitamin K has not been assessed before in the population of Sindh.
1- To assess Vitamin K level in newborns presenting with bleeding.
2- To determine demographic profile of VKDB patients.
Methods: This descriptive cross-sectional study was conducted at the department of Pathology and department of Pediatrics LUMHS from August 2018 till December 2019. Patients who met the criteria were selected from Paediatrics department. Detailed bleeding history and clinical examination of the patient was done. All patients underwent primary screening for bleeding including PT and APTT that was performed on Coagulation Analyzer CA- 600. Samples were analyzed using Vitamin K1 (VK1) ELISA Kit by Abbexa(UK). Data was analyzed using SPSS 20.
Results: Sample size was 114, with age ranging from day 01 up to day 180 (up to 6 months) out of which 56 were males and 58 were females. P- value: 0.03. The mean age was 44.01 days. PT, aPTT, were prolonged in almost all of the cases. Mean PT was recorded as 21.14 and mean aPTT was 51.84. Normal VK level found in 63.2%, whereas 36.8% had low Vitamin K level. (< 0.16 ng/ml).
Conclusions: Vitamin K deficiency presents with a variable pattern of bleeding. It is more frequent in male, preterm neonates.
To cite this abstract in AMA style:Hafeez N, Ujjan I, Tabassum S, Aamir K, Naz A. Assessment of Vitamin K Level in Newborn Presenting with Bleeding in Population of Rural Sindh, Pakistan [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/assessment-of-vitamin-k-level-in-newborn-presenting-with-bleeding-in-population-of-rural-sindh-pakistan/. Accessed May 16, 2021.
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