Abstract Number: PO125
Meeting: ISTH 2021 Congress
Theme: Coagulation and Natural Anticoagulants » Regulation of Coagulation
Background: Thromboembolic events are a public health problem worldwide. Oral anticoagulants are widely used for primary and secondary thromboprophylaxis. Adherence to oral anticoagulation is essential to achieve therapeutic goals.
Aims: This systematic review will assess the factors associated with adherence to treatment with coumarin derivatives or direct oral anticoagulants (DOACs).
Methods: Search strategies will be based on indexed terms from Medical Subject Heading (MeSH) and applied on MEDLINE/PubMed, EMBASE, CINAHL, and Latin American and Caribbean Health Sciences Information System (LILACS). Additional articles will be searched from gray literature and by manual search in the reference lists of selected studies. There will be no date limit or language restriction. Inclusion criteria: participants´ age >18 years, both sexes, on chronic anticoagulation with coumarin derivatives or DOACs, observational or experimental studies using any method to assess adherence to oral anticoagulation. Exclusion criteria: duplicates, experimental studies involving animals, narrative or systematic reviews and case reports/series. The titles and abstracts will be evaluated and the selected studies will be fully read. The data of interest will be extracted and presented in tables, including sociodemographic, behavioral, clinical, drug therapy data and analytical methods. Two independent reviewers will participate of the selection of articles and data extraction. The discrepancies will be resolved by a third reviewer, if necessary. Validated instruments will be used to assess the quality of studies according to the study design. The systematic review was approved by PROSPERO (code CRD42020223555) and will be conducted in accordance with the PRISMA 2020 statement.
Results: A total of 830 articles were retrieved in the initial search on MEDLINE (639), EMBASE (9), CINAHL (160) and LILACS (22).
Conclusions: Our findings are expected to contribute to the understanding of adherence to oral anticoagulation, bringing perspectives for the design of effective interventions in clinical practice.
To cite this abstract in AMA style:
Sousa W, Guimarães N, Viana C, Machado P, Medeiros A, Vianna M, Martins MA. Associated Factors of Adherence to the Use of Coumarin Derivatives or Direct Oral Anticoagulants: Protocol of a Systematic Review [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/associated-factors-of-adherence-to-the-use-of-coumarin-derivatives-or-direct-oral-anticoagulants-protocol-of-a-systematic-review/. Accessed October 2, 2023.« Back to ISTH 2021 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/associated-factors-of-adherence-to-the-use-of-coumarin-derivatives-or-direct-oral-anticoagulants-protocol-of-a-systematic-review/