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Association between FGB – 455 G/A and PAI-1 – 675 5G / 4G Gene Polymorphisms and Covid-19 Severity

B. Vatseba1, N. Virstyuk1

1Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine

Abstract Number: PO127

Meeting: ISTH 2021 Congress

Theme: COVID and Coagulation » COVID and Coagulation, Clinical

Background: Coronavirus infection (COVID-19) is characterized by an increased inflammatory response that can lead to serious manifestations, including coagulopathy. Limited data indicate a high incidence of DVT and pulmonary embolism in more than 40% of patients. Identifying specific genetic factors can help to determine the prognosis and management of such patients.

Aims: To determine the effect of PAI-1-675 and FGB – 455 G/A gene polymorphisms on the severity of Covid-19 disease course.

Methods: We examined 47 patients (ps) with laboratory-confirmed Covid-19 (26 females/21 males; age, 44.8±5.6 yr). Plasminogen activator inhibitor (PAI)-1-675 and beta-fibrinogen (FGB )455 G/A  gene polymorphism were analysed by PCR. Interleukin 6 (IL-6), D-dimer,  fibrinogen, C-reactive protein (CRP) and PAI-1 were measured by the immuno-assay method.

Results: Patients were divided into three groups: 9 (19.1%) ps with mild Covid-19 who were treated on an outpatient basis (I), 17 (36.2%) ps with moderate of Covid-19 who were hospitalized for bilateral pneumonia (II) and 21 (44.7%) ps with severe Covid-19 who were treated in intensive care for ARDS  and required oxygen therapy (III). The level of D-dimer in  group III  was 4.7 times higher than in  group I (p<0.001). Fibrinogen level in group III was 2.5 times higher than in group I (p<0.05).  In patients of group I PAI-1-675 5G/5G (100.0%), FGB-455 G/A (33.3%); in patients of group II – PAI-1-675 5G/4G (82.4%), FGB-455 G/A (47.1%); in patients of group III – PAI 1-675 5G/4G (38.1%) and PAI-1-675 4G/4G (61.9%), FGB-455 G/A (19.1%) and FGB-455 A/A (23.8%) were detected.  The median RAI-1 levels for the 5G/5G, 5G/4G, and 4G/4G  genotypes of this gene were 34.6, 79.8 and 172.6 μmol / l, (p = 0.002). The direct correlations between PAI-1 and IL-6, CRP (r=0,6209; r=0,6905;  accordantly; p<0,001) were detected.

Conclusions: FGB-455 G/A, PAI-1-675 5G/4G, and especially 4G/4G  gene polymorphism may be a predictors of severe Covid-19 disease.

To cite this abstract in AMA style:

Vatseba B, Virstyuk N. Association between FGB – 455 G/A and PAI-1 – 675 5G / 4G Gene Polymorphisms and Covid-19 Severity [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/association-between-fgb-455-g-a-and-pai-1-675-5g-4g-gene-polymorphisms-and-covid-19-severity/. Accessed August 8, 2022.

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