Abstract Number: PB0271
Meeting: ISTH 2021 Congress
Background: The 2019 novel coronavirus disease (COVID-19) is associated with significant thrombotic complications, contributing to the excess mortality observed with severe disease. Currently, there is insufficient evidence to support therapeutic dose anticoagulation in hospitalized COVID-19 patients outside of clinical trials. There is a greater need to understand the epidemiological and clinical factors associated with thrombotic complications.
Aims: To investigate the clinical characteristics in self-reported Asian race, who were hospitalized with COVID-19 early in the pandemic and the incidence of thrombosis.
Methods: We conducted a retrospective observational study of index hospitalizations for all patients, age ≥ 18, with confirmed SARS-CoV-2 infection between March 13 and April 4, 2020 across two hospitals in New York City. Clinical demographics including self-reported race and admission labs were collected. Confirmed arterial and/or venous thrombosis were confirmed with imaging during the encounter with chart review.
Results: There were 118 patients, who self-identified as Asian, hospitalized with COVID-19 during the study period. During their hospitalization, there were 24 patients (20.3%) who experienced thrombotic event during their encounter. There were 14 events described as venous thrombosis (7 deep venous thrombosis, 6 pulmonary embolisms, 1 superficial vein thrombosis) and 10 who experienced an arterial thrombosis (5 cerebrovascular accidents, 4 myocardial infarctions and 1 with splenic infarction). Body mass index (p = 0.027) and a history of cancer (p = 0.026) were significant demographic factors associated with thrombosis. D-dimer (p = 0.045), C-reactive protein (p < 0.001), ferritin (p = 0.024) and troponin I (p = 0.036) were significantly elevated on admission.
Conclusions: There are differences in clinical characteristics on admission in self-identified Asians, associated with thrombosis in COVID-19. Understanding these associated factors is helpful to delineate both the spectrum and pathophysiology of COVID-19.
To cite this abstract in AMA style:Theprungsirikul PP, Saith SE. Association between Race and the Incidence of Thrombosis in Hospitalized COVID-19 Patients Across a New York City Hospital System [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/association-between-race-and-the-incidence-of-thrombosis-in-hospitalized-covid-19-patients-across-a-new-york-city-hospital-system/. Accessed August 9, 2022.
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