Abstract Number: PB0825
Meeting: ISTH 2020 Congress
Background: Prophylaxis treatment has become the gold standard for treating hemophilia. The initiation of prophylaxis therapy may reduce the bleeding tendency in patients. Recent evidence shows that the prophylaxis regimen reduces bleeds and joint damage. However, reported adherence levels among patients with hemophilia to vary widely (17-93%). The level of adherence and its association with bleeding tendency and co-morbidity have not been well documented.
Aims: This study aims to evaluate severe hemophilia A patients´ adherence to prophylaxis regimen and to understand the association of bleeding and factors contributing to non-adherence.
Methods: This is an observational study with retrospective and prospective data collection conducted via patients’ interviews and review of patients’ medical records. Validated adherence scale (Veritas -Pro), comprises of 24 questions to be answered by each subject was used in this study. Patients with age of above 18 years old who are using prophylaxis regimens will be eligible for inclusion.
Results: A total of 38 patients were recruited. Median bleeding episodes per year was 5 episodes (0 to 19 episodes). 32 (84.2 %) of them experienced joint bleeding in the previous month, 22 (57.9%) had confirmed arthropathy, and 25 (65.8%) had other co-morbidities. Median adherence was 36.6 % (mean 39 %, range 25 % to 61%).
Conclusions: The median of bleeding rate of 5 in this study is smaller compared to on-demand group which may reach up to 12 median bleeding rates. This study has provided evidence showing a positive correlation of adherence to bleeding frequency and 65.8% had other co-morbidities.
To cite this abstract in AMA style:Mohd Mokhtar F, Sathar J, Bee PC, Zaman Huri H. Association of Adherence and Bleeding Frequency among Severe Hemophilia A Patients on Prophylactic Factor VIII [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/association-of-adherence-and-bleeding-frequency-among-severe-hemophilia-a-patients-on-prophylactic-factor-viii/. Accessed January 23, 2022.
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