Abstract Number: PB0512
Meeting: ISTH 2021 Congress
Background: Limited published data characterizing the relationship between participation in physical activity (PA) and frequency of bleeding in children with hemophilia A (CwHA) exist.
Aims: To examine the association between participation in PA and annualized bleed rate (ABR) among CwHA in a real-world setting.
Methods: Data from the Cost of Haemophilia across Europe-Socioeconomic Survey in Paediatric Population (CHESS PAEDs) study, conducted in France, Germany, Italy, Spain, and the United Kingdom during 2017, were utilized. Following ethics approval, hemophilia specialists provided information on CwHA they treated, including demographics, treatment type, and clinical outcomes. Patients completed quality-of-life-related questionnaires and reported activity levels (directly or via caregivers).
Results: Overall, 138 CwHA who reported participation in PA were included. The mean±standard deviation hours spent per week on PA were 23.8±24.8 and 10.8±11.3 for moderate and severe patients, respectively (Table 1). Mean ABRs were 4.3±7.9 and 6.9±18.7 for moderate and severe patients, respectively, and 9.19±27.2 and 5.75±13.7 for on-demand and prophylaxis patients, respectively. CwHA who engaged in vigorous PA were similar in age and BMI to those who did not, but had a higher proportion of on-demand users. The mean ABR was higher in CwHA who engaged in vigorous PA (8.0±21.0) compared to those who participated in only light and/or moderate PA (3.5±3.7); however, the median ABR and proportion with zero bleeds were similar. There was no clear trend in ABR between CwHA who adapted their treatment prior to engaging in PA compared to those who did not (Table 2).
Conclusions: This 2017 study suggests a slightly higher bleed frequency in CwHA with higher participation in PA, which could indicate that, although 78% of all CwHA were receiving prophylaxis, the treatment was suboptimal in real-world settings. However, these findings should be interpreted with caution considering the small sample and potential confounders.
To cite this abstract in AMA style:Ofori-Asenso R, Nissen F, Silkey M, Xu T, Yamaguchi-Suita H, Nosaka D, Aizenas M, Meier O, Burke T, O'Hara J. Association of Physical Activity with Bleeding Frequency in Children with Hemophilia A: A CHESS PAEDs Study Analysis [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/association-of-physical-activity-with-bleeding-frequency-in-children-with-hemophilia-a-a-chess-paeds-study-analysis/. Accessed December 8, 2021.
« Back to ISTH 2021 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/association-of-physical-activity-with-bleeding-frequency-in-children-with-hemophilia-a-a-chess-paeds-study-analysis/