Abstract Number: PB1621
Meeting: ISTH 2020 Congress
Background: This study attempted to reveal platelet derived- microparticles (MPs) interact with endothelial cells in the circulation after platelet activation in patients with atrial fibrillation.
Aims: We hypothesized that the elevated MPs was closely related to the prognosis of NVAF patients.
Methods: Aenous blood samples were drawn from 33 NVAF patients and 30 sinus rhythm controls from October 2018 to September 2019. Activation and mitochondrial Δψm depolarization of platelets were measured. Plasma levels of platelet and endothelial- derived MPs, von Willebrand factor (vWF) and endothelin (ET) were observed. The relationship between PMPs and prognosis of NVAF patients was assessed.
Results: Activation and higher mitochondrial Δψm depolarization of platelets were found in NVAF patients preoperatively. PMPs, EMPs, vWF and ET increased in NVAF group prior to PCI when compared to patients prooperatively or controls. Patients with elevated PMPs had higher rates of recurrences compared with those who had lower PMPs. Levels of PMPs but not EMPs were positively correlated with CHADS2 score.
Conclusions: NVAF accompanied with platelet activation and endothelia dysfunction. Increased PMPs released from activated platelets may predict the recurrence rates of atrial fibrillation.
To cite this abstract in AMA style:Ding B, He L, Zhou Y. Association of Platelet Derived – Microparticles and Endothelia Dysfunction in NVAF Patients Undertaking PCI [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/association-of-platelet-derived-microparticles-and-endothelia-dysfunction-in-nvaf-patients-undertaking-pci/. Accessed October 1, 2023.
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