Abstract Number: PB0761
Meeting: ISTH 2020 Congress
Background: A plaque may rupture with high risk of subsequent thrombus mediated acute clinical events such as myocardial infarction and stroke. Catheter-based lasers and shock wave generator systems have been extensively studied as effective methods to treat thrombosis.
Aims: The aim of this study was to generate a rabbit model of femoral artery thromboembolism occlusion and the subsequent investigating the feasibility of B- mode ultrasound- guided photomechanic- shock wave combination thrombolytic therapy accompanied by simultaneously intravenous streptokinase- loaded microbubbles administration in this model
Methods: Briefly, New Zealand White rabbits were submitted to thromboembolism occlusion by injecting autologous blood clots through femoral artery. Then treatment group underwent catheter- based Q-switched Nd: YAG laser (F= 532 nm, P= 30 W, PD= 5 ns) and low- level electrohydraulic pulsed- focused shock wave (V=10 Kv, F=0.5 Hz, Impulses= 200) thrombolytic therapy accompanied by simultaneously intravenous streptokinase (25000 Units/kg)- loaded PESDA (Perfluorocarbon- Exposed Sonicated Dextrose Albumin) microbubbles (100ml/kg, 2-5 × 105 bubbles/ml) administration, wherein diagnostic B- mode ultrasound is combined with therapy system, with a goal of increased safety.
Results: Results from B-mode ultrasonography and histopathology, showed a significant reduction in the mean value for thrombus content at the embolic region in the treatment group compared with the other groups (P< 0.05).
Conclusions: Enhanced thrombolytic effect of photomechanic- shock wave combination therapy, induced by inertial cavitation effect of microbubbles accompanied by enhanced thrombolytic effect of streptokinase, induced by sonoporation therapy effect of shock waves can cause to reduce the thrombus content and significantly dilate the luminal cross-sectional area at the embolic region and lower treatment time.
To cite this abstract in AMA style:Mehrad H, Farhoudi M. B- Mode Ultrasound-Guided Photomechanic-Shock Wave Combination Thrombolytic Therapy of Embolic Artery Accompanied by Simultaneously Streptokinase – Loaded Microbubbles Administration [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/b-mode-ultrasound-guided-photomechanic-shock-wave-combination-thrombolytic-therapy-of-embolic-artery-accompanied-by-simultaneously-streptokinase-loaded-microbubbles-administration/. Accessed March 3, 2021.
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