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Baropodometric Barefoot Analysis for Musculoskeletal Health Assessment in Congenital Hemophilia

R. Gualtierotti1, V. Begnozzi2, E. Boccalandro2, S. Braham2, M.E. Mancuso2, E. Santagostino2, F. Peyvandi2,3

1Università degli Studi di Milano, Department of Medical Biotechnology and Translational Medicine, Milan, Italy, 2Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy, 3Università degli Studi di Milano, Department of Pathophysiology and Transplantation, Milan, Italy

Abstract Number: PB0906

Meeting: ISTH 2020 Congress

Theme: Hemophilia and Rare Bleeding Disorders » Hemophilia - Clinical

Background: Hemophilic arthropathy and muscular hematomas are frequent complications of hemophilia that may impact the postural system. Baropodometric barefoot reliably measures the postural system energy consumption.

Aims: We aimed to investigate the correlation of baropodometric parameters with the hemophilia joint health score (HJHS) and the EQ-5D-5L, a health-related quality of life (HRQoL) tool in patients with hemophilia.

Methods: We evaluated 114 consecutive adult congenital hemophilia A and B patients referring to our center. In order to avoid confounding by incomplete motor-skill development or health conditions other than hemophilia, we investigated patients aged 18-65 and divided them into age classes (18-29/30-41/42-53/54-65) to better characterize musculoskeletal health variables, which are often dependent on age. Parameters obtained with baropodometric barefoot (Biopostural system Pod Base) over 51.2” in a standing position were correlated with HJHS and EQ-5D-5L by Spearman’s rho (p< 0.05=* and p< 0.001=**).

Results: Median age of patients was 41 years (interquartile range – IQR 28-50), 90% had hemophilia A, of whom 75% severe, 63% were regularly applying sport activities. The median HJHS was 9 (IQR 3-15).
All barefoot parameters except acceleration showed a slight but significant positive correlation with HJHS (rho 0.22-0.25). HJHS was strongly correlated with the age (0.47**). After dividing patients in age classes, none of the barefoot parameters correlated with HJHS or age, although they correlated with the physical domains of EQ-5D-5L (motility, self-care and usual activities). Patients aged 42-53 showed the strongest correlations between EQ-5D-5L motility, self-care and usual activities and variance of speed (0.47**; 0.53**; 0.61** respectively) and length function of surface (0.55**; 0.56**; 0.59** respectively).

Conclusions: Baropodometric barefoot provides useful information compared to HJHS and HRQoL tools in hemophilia patients. The EQ-5D-5L motility, self-care and usual activities domains, correlated strongly with barefoot parameters in patients aged 42-53.

To cite this abstract in AMA style:

Gualtierotti R, Begnozzi V, Boccalandro E, Braham S, Mancuso ME, Santagostino E, Peyvandi F. Baropodometric Barefoot Analysis for Musculoskeletal Health Assessment in Congenital Hemophilia [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/baropodometric-barefoot-analysis-for-musculoskeletal-health-assessment-in-congenital-hemophilia/. Accessed September 24, 2023.

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