Abstract Number: PB0906
Meeting: ISTH 2020 Congress
Background: Hemophilic arthropathy and muscular hematomas are frequent complications of hemophilia that may impact the postural system. Baropodometric barefoot reliably measures the postural system energy consumption.
Aims: We aimed to investigate the correlation of baropodometric parameters with the hemophilia joint health score (HJHS) and the EQ-5D-5L, a health-related quality of life (HRQoL) tool in patients with hemophilia.
Methods: We evaluated 114 consecutive adult congenital hemophilia A and B patients referring to our center. In order to avoid confounding by incomplete motor-skill development or health conditions other than hemophilia, we investigated patients aged 18-65 and divided them into age classes (18-29/30-41/42-53/54-65) to better characterize musculoskeletal health variables, which are often dependent on age. Parameters obtained with baropodometric barefoot (Biopostural system Pod Base) over 51.2” in a standing position were correlated with HJHS and EQ-5D-5L by Spearman’s rho (p< 0.05=* and p< 0.001=**).
Results: Median age of patients was 41 years (interquartile range – IQR 28-50), 90% had hemophilia A, of whom 75% severe, 63% were regularly applying sport activities. The median HJHS was 9 (IQR 3-15).
All barefoot parameters except acceleration showed a slight but significant positive correlation with HJHS (rho 0.22-0.25). HJHS was strongly correlated with the age (0.47**). After dividing patients in age classes, none of the barefoot parameters correlated with HJHS or age, although they correlated with the physical domains of EQ-5D-5L (motility, self-care and usual activities). Patients aged 42-53 showed the strongest correlations between EQ-5D-5L motility, self-care and usual activities and variance of speed (0.47**; 0.53**; 0.61** respectively) and length function of surface (0.55**; 0.56**; 0.59** respectively).
Conclusions: Baropodometric barefoot provides useful information compared to HJHS and HRQoL tools in hemophilia patients. The EQ-5D-5L motility, self-care and usual activities domains, correlated strongly with barefoot parameters in patients aged 42-53.
To cite this abstract in AMA style:Gualtierotti R, Begnozzi V, Boccalandro E, Braham S, Mancuso ME, Santagostino E, Peyvandi F. Baropodometric Barefoot Analysis for Musculoskeletal Health Assessment in Congenital Hemophilia [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/baropodometric-barefoot-analysis-for-musculoskeletal-health-assessment-in-congenital-hemophilia/. Accessed May 18, 2021.
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