Abstract Number: PB0726
Meeting: ISTH 2021 Congress
Theme: Hemophilia and Rare Bleeding Disorders » Rare Bleeding Disorders
Background: Despite the typical phenotype of the bleeding coagulopathies, these disorders do not prevent the affected patients from the development of the thromboembolism. The major contributing factors for thrombosis in these cases are the traditional risk factors, such as advanced age, arterial hypertension, hyperlipidemia, smoking, immobilization, surgery, pregnancy, and also the coexistence of the thrombophilic state, substitution treatment and the use of by-passing agents.
Aims: To discuss the management of the coincidence of bleeding and thrombosis in several patients.
Methods: The authors present two case reports of the patients with bleeding coagulopathy who developed thromboembolic complications and report on the successful management of their challenging clinical states.
Results: The antithrombotic treatment was administered without any complications. The patient with coagulation factor VII deficiency and iliofemoral deep vein thrombosis plus subsequent combined central retinal arterial and venous occlusion is presented. Moreover, the authors describe the management of the patient with hemophilia A and venous thrombosis, who subsequently developed arterial thrombosis.
Conclusions: Older patients with bleeding disorder of hemostasis have prothrombotic risk factors comparable with that of general population. In the concomitant existence of several prothrombotic risk factors, the risk of the development of thrombosis is increased. Generally, there is a lack of large studies supporting the universal guidelines for such situations. Therefore, the combination of the substitution and antithrombotic treatment should be individualized.
The project complies with the Declaration of Helsinki and the informed consent in each patient is obtained.
Acknowledgements: Authors thank the support of the projects of the Scientific Grant Agency (Vega)1/0549/19 and Agency for the Support of Research and Development APVV-16-0020.
To cite this abstract in AMA style:
Stanciakova L, Dobrotova M, Holly P, Brunclikova M, Bolek T, Samos M, Kubisz P, Stasko J. Bleeding and Thrombosis in One Patient – Management of Challenging Disorders of Hemostasis [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/bleeding-and-thrombosis-in-one-patient-management-of-challenging-disorders-of-hemostasis/. Accessed September 22, 2023.« Back to ISTH 2021 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/bleeding-and-thrombosis-in-one-patient-management-of-challenging-disorders-of-hemostasis/