Background: Since the introduction of episodic and prophylaxis treatment with safer products, the life expectancy of people with haemophilia enhanced considerably. This comes with an increasing number of older patients with hemophilia and with associated diseases, such as cardiovascular disease.

Aims: HemoCardio was a cross-sectional study aimed to describe CVD risk factors among North-eastern Brazilian people with haemophilia.

Methods: Male patients 30 years or older were interviewed, had physical examinations and provided blood samples.

Results: Eighty-four patients were included, of whom 83.3% had haemophilia A and half had severe disease. Median age at study entry was 42.0 years [interquartile range IQR, 36.0-51.0]. Obesity, systemic arterial hypertension and diabetes frequencies were 15.7%, 58.2% and 15.9%, respectively. Hypertriglyceridaemia, hypercholesterolaemia and hypoHDLaemia were present in 17.5%, 43.1% and 31.0%, respectively. Metabolic syndrome was considered in 36.8%. Major electrocardiogram changes were described in 29.5%. There were 46.7% patients with high risk of developing cardiovascular events in the next 10 years, according to the Framingham risk score. Several reports from general Brazilian men described a prevalence of high-risk Framingham risk score ranging from 4.7% to 12.7%.

Conclusions: In conclusion, our findings suggest a relatively high prevalence of CVD risk factors and associated CVR risk score among men with haemophilia compared with the general male population.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/cardiovascular-risk-factor-profile-among-north-eastern-brazilian-adults-with-haemophilia/