Abstract Number: PB0071
Meeting: ISTH 2020 Congress
Theme: Arterial Thromboembolism » Cardiovascular Risk Factors
Background: Patients with systemic lupus erythematosus (SLE) seem to have higher cardiovascular risks (CVR) as they combine traditional and non- traditional CVR factors.
Aims: To determine the CVR in SLE patients and its correlation with disease activity and systemic manifestations.
Methods: Medical records of 89 patients diagnosed with SLE according to the modified ACR criteria of 1997 were retrospectively analyzed. CVR was assessed using the Framingham Risk Score to estimate the 10 years CVR. It’s considered low if less than 10%; moderate if it’s between 10 à 20% and high if over 20%.
Results: The mean age was 35 years with a sex ratio M/F= 0.1. About 3.4% of the patients were smokers, 4.5% diabetics, 10.1% with high blood pressure and 3.4% dyslipidemic. The mean Body mass index was 25.9 kg/m2. Mean cholesterol levels were 4.38 mmol/l, Triglyceride 2.04, HDL 1.38 and LDL 1.74. Mean SLEDAI score was 9 and mean Framingham score was 2.58%. The CVR was considered low in 55.6% of the patients and moderate in 44.4%. Framingham score was inversely correlated with renal clearance (p=0.037) and neutrophile to lymphocyte ratio (p=0.06) without reaching the significant level. There was no correlation with disease activity, inflammatory parameters or systemic manifestations.
Conclusions: Despite the high disease activity in our patients and the high levels of inflammatory parameters, no one of our patients was presenting with high CVR according to Framingham score. Thus, the latter seems not suitable to estimate the CVR in inflammatory diseases especially SLE.
To cite this abstract in AMA style:
Kechida M, Fraj A, Daada S, Klii R, Hammami S, Sassi M, Khochtali I. Cardiovascular Risk in Systemic Lupus Erythematosus [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/cardiovascular-risk-in-systemic-lupus-erythematosus/. Accessed March 21, 2024.« Back to ISTH 2020 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/cardiovascular-risk-in-systemic-lupus-erythematosus/