Abstract Number: PO171
Meeting: ISTH 2021 Congress
Background: Therapy for childhood acute lymphoblastic leukaemia (ALL) is performed using intense chemotherapy protocols with a high risk of therapy-related complications such as thrombosis. Chemotherapy agents, infections are some of the factors which contribute increased risk of thrombosis.
Aims: The aim of this study is to evaluate the frequency of cerebral thrombosis in children who were treated for ALL.
Methods: For this purpose the clinical records of 153 patients diagnosed with ALL and treated with ALL-Berlin-Frankfurt-Münster (BFM) treatment protocol in the Department of Pediatric Hematology of Istanbul Medeniyet University Prof Dr Suleyman Yalcın Training Hospital between August 2009 and January 2021 were analyzed retrospectively.
Results: Of 153 patients 62 (40.5%) were female, 91(59.5%) were male, aged between 7 months-17.8 years, mean age 9.3 years. Of these 18 patients were diagnosed with T-cell ALL, 135 with precursor B-cell ALL. We observed cerebral thrombosis in two (1.3%) patients. The characteristics of these patients:
Case1: A 5.8 year-old-girl diagnosed with common-ALL, in standard risk group, developed superior sagital sinüs thrombosis on the 43rd day of remission induction chemotherapy.
Case 2: A 8.5 yer-old-boy diagnosed with common-ALL, in median risk group, developed superior sagittal sinüs thrombosis on the 29th day of remission induction chemotherapy.
Inherited thrombophilia screening tests were negative for both of the patients and thrombosis was likely due to L-asparaginase. They were treated with low molecular weight heparin successfully. Anticoagulant treatment was continued until the end of the chemotherapy. They continued to receive L-asparaginase according to the treatment protocol and they did not have recurrence.
Conclusions: Sinus venous thrombosis represents one of the serious chemotherapy-related complications in childhood ALL. Especially L-asparaginase is significantly related with development of thrombosis. We need more studies to be done to establish the optimal duration for treatment of cerebral thrombosis in childeren.
To cite this abstract in AMA style:Canbolat Ayhan A. Cerebral Thrombosis during Treatment of Childhood Acute Lymphoblastic Leukemia [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/cerebral-thrombosis-during-treatment-of-childhood-acute-lymphoblastic-leukemia/. Accessed November 29, 2021.
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