Abstract Number: PB0063
Meeting: ISTH 2020 Congress
Background: The adequate functioning of the hemostatic system determines the cardiovascular system health. Under the influence of high physical exertion, the heart and blood
vessels experience tremendous stress, compensation is possible only under conditions of all systems harmonious operation.
Aims: The study included a grou p of athletes engaged in various sports.
Methods: Among 98 athletes, a study of the hemostasis system proteins genes was conducted,
and the functional state of the fibrinolytic system was also assessed. The genetic variant of Leiden Factor V is found in 3.6% of athletes (95% CI: 0.6-8.5%). In 77.4% of cases (95% CI: 67.9 – 85.7%), an SERPINE1 -675 4G gene allelic variant was found.
Results: The allelic variant of the fibrinogen gene -455A was noted in 40.5% of athletes (95%
CI: 30.3 – 51.1%). The integrin beta-3 protein gene 1565C variant was 25% (95% CI: 16.3 – 34.8%). Due to evaluation of fibrinolytic activity, a significant decrease in the plasminogen tissue activator level (M = 0.73 [0.61-0.88]), an increase in the plasminogen activator inhibitor level of the first type PAI-1 (Me = 29.89 [22.3; 47.3]) were revealed. A direct correlation was found between the presence of the allelic variant of the SERPINE1-675 4G gene carriage and the level of PAI-1 in the blood plasma (rs = 0.29, p ≤ 0.05).
Conclusions: Indicators of fibrinolytic status defin e the inhibition of fibrinolysis activity. A higher
prevalence of allelic variants of genes determining the increased risk of developing
thrombophilic conditions in athletes compared with the population of the North-West of the Russian Federation was shown. The reported study was funded by RFBR according to the research project No18-00-00814-KOMFI (18-00-0047818).
To cite this abstract in AMA style:Vorobyeva N, Malishkina N. Changes in the Hemostasis System in Athletes [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/changes-in-the-hemostasis-system-in-athletes/. Accessed August 15, 2022.
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