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Changes of Soluble Fibrin-Monomer Complex Concentration in Different Types of Coronary Artery Disease

1Bogomolets National Medical University, Internal Medicine #4, Kyiv, Ukraine, 2Bogomolets National Medical University, Kyiv, Ukraine, 3Taras Shevchenko National University of Kyiv, ESC “Institute of Biology and Medicine”, Biochemistry, Kyiv, Ukraine

Abstract Number: PB0015

Meeting: ISTH 2020 Congress

Theme: Arterial Thromboembolism » Acute Coronary Syndromes

Background: Soluble fibrin-monomer complex (SFMC) as a feature of thrombosis is shown to be raised in patients with acute coronary syndrome (ACS). Most studies exist regarding myocardial infarction (MI). Limited investigations include patients with unstable angina (UA). Almost no data is found concerning types of UA, namely, new-onset (NUA) and crescendo (CUA) angina.

Aims: To compare the concentration of SFMC in patients with different types of CAD (MI, NUA, CUA, stable angina (SA)).

Methods: In this cross-sectional study, we collected blood samples in 94 patients with CAD – 10 patients with MI, 57 patients with UA (38 patients with PUA and 19 patients with NUA), 27 patients with SA. Concentration of SFMC was determined by colorimetric ortho-phenantroline method. There were no significant difference between groups with respect of age (63,66+/-7,79 y.o.), gender (females:males=33,7:66,3) and body mass index (28,91+/-4,53 kg/m2). Written consent was obtained from each participating subject. The data was analysed with SPSS v.22.

Results: We have identified increased SFMC concentration in ACS patients compared with SA (22,00 (12,00-26,00) mcg/ml vs 15,00 (9,75-21,50) mcg/ml, p=0,03). SFMC concentration in UA (22,00 (11,00-28,00) mcg/ml) was higher than in SA (p=0,016), and did not differ from MI patients´ concentration (22,00 (15,00-26,00) mcg/ml, p>0,05). SFMC concentration in NUA was higher in comparison with CUA (24,00 (22,00-28,00) mcg/ml vs 19,00 (7,50-25,75) mcg/ml, p=0,013). There were no difference between SFMC concentration in SA vs CUA (p>0,05) and MI vs NUA (p>0,05). The association between types of CAD and SFMC concentration was established (Chi28=30,691, p=0,0001, Cramer´s V=0,375).

Conclusions: We have found dissimilarity of SFMC concentration depending on CAD type (including the one between NUA and CUA). The statement about increased thrombotic activity in patients with ACS need more profound analysis.

  SFMC≤10 mcg/ml, % 10 SFMC≥20 mcg/ml, %  
Stable angina 23,1 50,0 26,9 100%
Crescendo angina 29,4 20,6 50,0 100%
New onset angina 5,3 0 94,7 100%
Myocardial infarction 0 30,0% 70,0 100%

[Dissimilarity of SFMC concentration depending on CAD type]

To cite this abstract in AMA style:

Tyravska Y, Lizogub V, Pliskevych D, Vovk T, Savchuk O. Changes of Soluble Fibrin-Monomer Complex Concentration in Different Types of Coronary Artery Disease [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/changes-of-soluble-fibrin-monomer-complex-concentration-in-different-types-of-coronary-artery-disease/. Accessed October 1, 2023.

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