Abstract Number: PB1807
Meeting: ISTH 2020 Congress
Background: Thrombocytopenia is one of the most common toxicities of chemotherapy. It can cause from mild petechiae up to debilitating bleeding, as well as lead to treatment delays and discontinuation, which subsequently affects the outcomes. The data on chemotherapy induced thrombocytopenia (CIT) is scarce, especially from the developing world and until now there is no consensus on the appropriate management of this complication.
Aims: The aim of this study was to evaluate CIT in pediatric patients with acute lymphoblastic leukemia (ALL).
Methods: Medical records of ALL patients, who were diagnosed and treated in 2019 at the Pediatric Cancer and Blood Disorders Center of Armenia, the only center treating pediatric hematologic and oncologic disorders in Armenia, were retrospectively reviewed.
Results: A total of 29 patients with ALL treated with ALL BFM 2009 protocol, who achieved remission, were included in the current study. 17 (58%) patients were males. Median age was 4.5y, range – [18 months – 17 years]. 5 patients had T-ALL and 24 patients B-ALL. During induction therapy 11 patients (38%) developed critical thrombocytopenia, platelet (PLT) counts ranging from 21×10⁹/L to 46×10⁹/L. During consolidation therapy 16 patients (55%) developed moderate thrombocytopenia, PLT counts ranged from 70×10⁹/L to 86×10⁹/L and 6 (21%) patients had critical thrombocytopenia, PLT counts ranged from 27×10⁹/L to 36×10⁹/L. During re-induction phase of therapy 21 (72%) patients developed critical CIT with platelet counts ranging from 13×10⁹/L to 45×10⁹/L.
Conclusions: During the course of therapy the vast majority of patients with ALL developed clinically significant thrombocytopenia. Although our study is small and involve the cases from one year, it includes all the ALL patients treated in Armenia. The study clearly shows that chemotherapy induced thrombocytopenia is a very common complication of ALL therapy and larger studies need to explore these findings.
To cite this abstract in AMA style:Gizhlaryan M, Sahakyan L, Krmoyan L, Petrosyan M, Melnichenko I, Anastasiadi M, Danelyan H, Danielyan S, Tamamyan G, Vagharshakyan L. Chemotherapy – Induced Thrombocytopenia in Pediatric Acute Lymphoblastic Leukemia: A Single-institution Report [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/chemotherapy-induced-thrombocytopenia-in-pediatric-acute-lymphoblastic-leukemia-a-single-institution-report/. Accessed August 15, 2022.
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