Abstract Number: PB1119
Meeting: ISTH 2021 Congress
Background: Venous thromboembolism (VTE), defined as pulmonary embolism or deep vein thrombosis, is the second leading cause of mortality in cancer patients, second only to cancer itself. A number of reports suggest that circulating extracellular vesicles (EVs) may be increased in cancer patients with VTE.
Aims: The aim of this study was to determine if circulating EVs are higher in cancer patients with VTE compared to those without VTE.
Methods: A comprehensive literature search was performed systematically in the databases Embase and MEDLINE from inception until April 20th, 2020. Study selection was performed by 2 authors independently. The pooled standardized mean difference (SMD) for EVs of any phenotype were compared between patients with and without VTE, and the summary odds ratio (OR) for VTE was estimated using random-effects meta-analysis.
Results: A total of 21 studies met the inclusion criteria and consisted of 9 cohort studies, 8 case-control studies, 3 cross-sectional studies, and 1 randomized control trial. The levels of Tissue Factor (TF)-bearing EVs were higher in cancer patients presenting with VTE than in cancer patients that did not have VTE (pooled SMD 1.27; 95% confidence interval [CI], 0.27-2.27; P < 0.001; I2 = 95%). The SMD in case-control studies was 1.43 (95% CI, -0.02-2.87; I2 = 96%) and that in cohort studies was 1.09 (95% CI: 0.27-1.91, I2 = 88%). The overall OR for VTE was 2.68 (95% CI, 1.69-4.25; I2 = 59%). Similar results were found for EV analysis detection methods. Analysis for publication bias testing and sensitivity and subgroup analysis is ongoing.
Conclusions: Our meta-analysis demonstrates that EV levels are increased in cancer patients with VTE. These data suggest that EVs may be a biomarker of VTE in individuals with cancer.
To cite this abstract in AMA style:Varol O, Burger D, Tritschler T, Wells P. Circulating Extracellular Vesicles in Patients with Cancer and Venous Thromboembolism: A Systematic Review and Meta-analysis [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/circulating-extracellular-vesicles-in-patients-with-cancer-and-venous-thromboembolism-a-systematic-review-and-meta-analysis/. Accessed November 29, 2021.
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