Abstract Number: PB0433
Meeting: ISTH 2021 Congress
Background: Acquired haemophilia A (AHA) is a rare bleeding phenotype, usually associated with autoimmune disease, where patients experience bleeding with unknown family history of bleeding disorder.
Aims: This study aims to provide an overview of clinical characteristics observed in patients with acquired haemophilia in France, Germany, Italy, Spain and UK.
Methods: Ipsos’ Haemophilia Therapy Monitor is a multi-country, multi-centre online medical chart review study of patients with haemophilia A (HA) and haemophilia B (HB) conducted from November 2020 to January 2021. De-identified data on patients in France, Germany, Italy, Spain and UK were collected from treating physicians recruited from an access panel; physicians were screened for duration of practice in their specialty and minimum caseload managed (5 HA and 1 HB moderate-severe patients in the last six months). 183 sampled physicians provided data on 1212 HA patients, of which 97 had AHA.
Results: Across the 97 AHA patients, the main comorbidities were metabolic disorder (46%), lung and heart disease (19%) and musculoskeletal conditions (14%).
35% (n=34) of the AHA patients experienced target joints prior to their most recent visit to the haematologist, and reported the most prevalent locations as being knees (62%, n=21), elbows (29%, n=10) and wrists (21%, n=7).
68% (n=66) of patients experienced bleeds in the last 12 months; spontaneous bleed (42%, n=28) and trauma (38%, n=25) were the most frequent cause of bleeding reported.
All AHA patients had inhibitors currently detected. Increased dose of factor VIII (48% of AHA pts) and by-passing agents (46%) were the main treatment approach in these patients.
Conclusions: Results from this present study highlight the presence of other autoimmune comorbidities, along with bleeds and target joints, experienced by AHA patients. Additional research would yield further understanding of other clinical aspects of this rare bleeding disorder.
To cite this abstract in AMA style:Palau I, Brown S, Rosli A, Seth E. Clinical Characteristics of Acquired Haemophilia A Patients in 5 European Countries [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/clinical-characteristics-of-acquired-haemophilia-a-patients-in-5-european-countries/. Accessed December 6, 2021.
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