Background: To identify patients whose hemoglobin (Hb) levels can decrease after autologous blood donation may contribute to effective and safe autologous blood transfusion.

Aims: In this study we aimed to determine the correlations of baseline laboratory markers before autologous blood donation with decrease of Hb levels after first blood drawing.

Methods: Patients undergoing major orthopedic surgery consisting of 35 males and 111 females were enrolled. Hb change was defined as the decrease or differences of Hb from first 400 ml blood drawing. Laboratory data were obtained in the hospital laboratory. Data were analyzed using Steel-Dwass multiple tests and Wilcoxon rank sum test (Mann-Whitney U test).

Results: Body height, body weight and body mass index (BMI) had no correlations with Hb change. Gender showed no significant correlation to change of Hb.  Higher levels of baseline red blood cells (RBC)，Hb，hematocrit (Ht) correlated with lower Hb levels after donation. Higher levels of RBC and Ht exhibited lower Hb recovery rate. Reticulocyte (Ret) levels before blood donatiuon negatively correlated with Hb change. Ret levels before blood donation positively correlated with Hb recovery amount and Hb recovery rate. In contrast, serum iron，unsaturated iron binding capacity，total iron binding capacity，ferritin，estimated glomerular filtration rate, and non-transferrin binding iron levels had no correlations with Hb change, Hb recovery amount and Hb recovery rate.

Conclusions: The results suggested that Ret can be used as a predictor for estimating Hb levels of donors after blood donation. Donors with higher Hb and Ht would have greater decrease of Hb than donors with lower Hb and Ht.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/clinical-factors-predicting-decrease-in-hemoglobin-levels-during-preoperative-autologous-blood-donation-by-patients-undergoing-major-orthopedic-surgery/