Abstract Number: PB0077
Meeting: ISTH 2020 Congress
Background: Hypertension, dyslipidemia, diabetes mellitus and obesity are the major risk factors of coronary artery disease (CAD). It has been known that atherosclerosis is a major cause of CAD. It has been reported that white blood cells (WBC) count and platelet indices play the important roles in the promotion of vascular injury and endothelial cell damage in individuals with risk factors of CAD.
Aims: Therefore, this study aimed to evaluate the association of hematological parameters including WBC and platelet with the risk of CAD risk factors along with other biological parameters.
Methods: A case-control study was performed in 220 individuals who underwent to Dokkhamtai hospital, Phayao province, Thailand for annual health check-up since 2015-2018. Based on baseline characteristics, participants were classified into two groups; healthy control (n=106) and individuals with risk factors (n=114).
Results: The results show that participants with CAD risk factors had higher levels of WBC count, mean platelet volume (MPV) and platelet distribution width (PDW) than healthy groups (P< 0.05). Moreover, WBC count was associated with BMI, SBP, uric acid, and triglyceride. In addition, PDW was related to SBP (p=0.018). Thus, these results indicated that WBC count and PDW may contribute to obesity, hypertension and dyslipidemia. Furthermore, high MPV levels (OR [95%CI]=2.72 [1.18-6.24], P< 0.001) and PDW (OR [95%CI]=1.83 [1.08-3.10], P< 0.001) were also associated with increased risk of obesity and hypertension, respectively. However, the correlation of hematological parameters with diabetes mellitus was not observed.
Conclusions: In conclusion, this study suggested that hematological parameters were associated with risk of major risk factor for CAD which may indicate that these hematological parameters can be used to evaluate the risk of major risk factors and CAD in healthy individuals.
To cite this abstract in AMA style:Lasom S, Chainam K. Clinical Implications of White Blood Cell Count and Platelet Indices in Individuals with Risk Factor of Coronary Artery Disease [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/clinical-implications-of-white-blood-cell-count-and-platelet-indices-in-individuals-with-risk-factor-of-coronary-artery-disease/. Accessed October 2, 2023.
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