Abstract Number: PB1216
Meeting: ISTH 2021 Congress
Theme: Venous Thromboembolism » VTE Epidemiology
Background: Cerebral venous sinus thrombosis (CVST) is a rare form of cerebrovascular disease, accounting for 0.5-1% of all strokes.
Aims: To review associations with the development of CVST including patient behaviours and characteristics. To review outcomes of anticoagulant therapy.
Methods: Retrospective single centre observational study over 4 years practice. Patients diagnosed with CVST between December 2016 and December 2020 were included. A diagnosis of CVST was confirmed by either CT +/- angio/ venography or MRI +/- angio/ venography. We reviewed clinical records for patient characteristics and provoking factors for venous thromboembolism (VTE) and evidence of thrombotic and haemorrhagic events whilst on anticoagulation.
Results: Among total 17 patients included, the mean age was 42 years (range 21–88) and the majority of patients were female (70.6%). None of the patients had a previous history of VTE.
11 patients had one or more risk factors for thrombosis at the time of diagnosis. This included active use of COCP in 7 out of 12 female patients (58.3%), local and systemic infections in 4 patients (23.5%); antiphospholipid syndrome (APS) in 5 patients (33%), and antithrombin deficiency in 1 patient (6.6%) out of 15 patients tested for APS and thrombophilia.
There was no reported recurrent thrombotic event during a median duration of 20 months follow up (range 3-47). No major bleeding occurred and only one patient reported CRNMB due to vaginal bleeding related to her underlying cervical cancer.
Conclusions: In our cohort the majority of patients affected were female and were strongly associated with APS and use of the COCP both of which may induce a state of activated protein C resistance. No recurrent CVST or other form of VTE was reported during follow up.
To cite this abstract in AMA style:
W Htut T, G Watson H, Mackay G, M Khan M. Clinical Observations in Patients with Cerebral Venous Sinus Thrombosis [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/clinical-observations-in-patients-with-cerebral-venous-sinus-thrombosis/. Accessed March 22, 2024.« Back to ISTH 2021 Congress
ISTH Congress Abstracts - https://abstracts.isth.org/abstract/clinical-observations-in-patients-with-cerebral-venous-sinus-thrombosis/