Abstract Number: PB1114
Meeting: ISTH 2021 Congress
Background: During the last year, 1 558 deaths were caused by Hematologic Malignancies (HM) in Cuba. Patients with Hematologic Malignancies (HM) are at high risk of venous thromboembolism (VTE). Some clinical risk factors have been related to thrombotic events, but prophylaxis in hospitalized patients is still inconsistent and not risk adjusted in our country.
Aims: To identify clinical risk factors associated to VTE and to determine overall survival (OS) in patients with HM.
Methods: A case-control study was carried out at Arnaldo Milián University Hospital in Santa Clara, Cuba from January 2018 to January 2021. The study population was 222 patients (66 with VTE, 156 without VTE), hospitalized with a diagnosis of HM. For the univariate analysis chi-square test, Odds Ratio (OR) with 95% confidence interval and Cramer’s V were applied. The logistic regression was performed to identify potential predictors of VTE in the multivariate analysis. OS was determined by the Kaplan Meier method. Informed consent was obtained and the study was approved by a medical ethics committee according to the Declaration of Helsinki.
On univariate analysis, variables associated with an increased VTE risk were: bedding (OR=5.73, p 0.000), diabetes mellitus (OR=4.54, p 0,000), hypercholesterolemia (OR=5.48, p 0.000), tumoral activity(OR=7.22, p 0.000), obesity (OR=2.50, p 0.012), history of prior thrombosis(OR= 3.52, p 0.002) and use of thrombogenic drugs( OR=1.95, p 0.030), mainly steroids and hormonal therapy. By logistic regression bedding, tumoral activity, diabetes mellitus, hypercholesterolemia and the use of thrombogenic drugs were identified as predictive factors. At 36 months, the OS of patients without VTE were 67.5% vs 31.8% in the group with VTE (figure 1).
Conclusions: Several risk factors are associated to the occurrence of VTE in patients with HM. VTE has an important role in the diminished OS of this patients.
To cite this abstract in AMA style:López Sacerio A, Alvarez Basulto N, Acosta Alvarez M, Tejeda Ramón MC. Clinical Risk Factors for Venous Thromboembolism in Hematologic Malignancies [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/clinical-risk-factors-for-venous-thromboembolism-in-hematologic-malignancies/. Accessed November 29, 2021.
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