Background: Cerebral venous sinus thrombosis (CVST) is a rare and life-threatening cerebrovascular disease in children.

Aims: In this study, clinical presentations, prothrombotic risk factors, thrombosis localization, and anticoagulant treatment results of children with CVST were evaluated.

Methods: Between January 2011 and September 2018, 29 patients (0-18 years) diagnosed with CSVT in Eskişehir Osmangazi University Faculty of Medicine, Department of Child Health and Diseases were retrospectively examined.

Results: Twentty nine children were included in this study, 15 (51.72%) were male and 14 (48.28%) were female. Median age was 11 years (3 days-17 years). The most common neurological symptoms and signs were headache, vertigo, seizure, hemiparesis. At least one clinical and / or hereditary thrombophilic risk factor was detected in 89.66% of patients. The most common clinical risk factors were infections, venous catheter and dehydration. The most common inherited thrombophilic risk factors were Heterozygous Factor V Leiden Mutation and high lipoprotein (a). The most common thrombosis localization was the transverse sinus. All patients received anticoagulant therapy. No child with CVST died from his or her thrombotic episodes. Epilepsy developed in five patients, hydrocephalus in one patient, and intracranial hypertension in one patient.

Conclusions: Clinical and hereditary thrombophilic risk factors should be well known to clinicians in CVST. It should be remembered that the risk of acute complications and long-term sequela can be significantly reduced with the appropriate treatment approach initiated early in the early diagnosis.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/clinical-spectrum-and-prothrombotic-risk-factors-of-cerebral-venous-sinus-thrombosis-in-children/