Abstract Number: PB0309
Meeting: ISTH 2020 Congress
Background: Although hemophilia comprehensive care was improved theses years in China. Intracranial hemorrhage (ICH) is still a serious and not rare complication in children with hemophilia.
Aims: This study was to retrospectively analyze the clinical data of childre’s intracranial hemorrhage with hemophilia in Hemophilia Comprehensive Management Center in China in order to to sum up the characteristics for the further clinical diagnosis and treatment.
Methods: The clinical data of total 19 children with hemophilia A or hemophilia B diagnosed ICH in Nanfang Hospital from 2016.1 to 2019.6 were enrolled.
Results: Among children with ICH, 73.7% (14/19) were hemophilia A and 26.3% (5/19)were hemophilia B. Severe hemophilia children counted 52.6%(10/19), meanwhile the proportion of children with intermediate type was also reached to 9/19 (47.4%). The median age occurred ICH was 17 months. There was 63.2%(12/19) of children with spontaneous bleeding and 36.8% (7/19) occurred after trauma . After ICH, 52.6% (10/19) of children had recurrent ICH . Nervous system sequelae occurred in 31.6% (6/19) of patients, and 1 case died of brain stem hemorrhage 1/19 (5.3%). About 94.7% (18/19) of ICH children did not underwent surgical treatment. About 78.9% (15/19) of ICH occurred at more than one site in CT imaging. Seven(7/19 ,36.8%) patients developed inhibitor after ICH, and all of them with high titers inhibitor. Before the onset of ICH, 57.9%(11/19) of the children was in on demand treatment, and 42.1% (8/19) of them was in prophylaxis.
Conclusions: Intermediate hemophilia children was also in risk of ICH as well as severe patients. Most of them are spontaneous intracranial hemorrhage, easy to occur in multiple sites in one bleeding episode, and with high risk of recurrence. Most of the ICH did not need surgical treatment. ICH patients need more monitor for inhibitor.
To cite this abstract in AMA style:Feng X, Ge H. Clinical Study of Children’s Intracranial Hemorrhage in Single Hemophilia Center in China [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/clinical-study-of-childrens-intracranial-hemorrhage-in-single-hemophilia-center-in-china/. Accessed October 1, 2023.
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