Background: Bernard-Soulier syndrome (BSS) is an inherited platelet bleeding abnormality, characterized by a prolonged bleeding time, large platelets and thrombocytopenia. Many scientific works have been carried out to evaluate the benefit of different parts of papaya plant including fruits, seeds, leaves, rind, shoots, roots or latex.

Aims: To evaluate the efficacy of papaya leaves extract in management of thrombocytopenia and bleeding frequency in children with BSS.

Methods: Fifteen patients diagnosed as BSS were included in this study with age up to 15 years , during period from 2008 to 2018 at pediatric hematology unit of Zagazig University Hospital. Consent from patients and their life care were taken IRB of faculty of medicine of Zagazig university. Acceptance was confirmed. Full history and complete examination was taken especially for annual bleeding rate and frequency of platelet transfusion per year and Platelet counts before and after of start of papaya leaves extract (sweeten with honey given in dose of 5ml to 10 ml according to age every day.

Results: There were significant decrease of bleeding episode per year after treatment with significant decrease platelet transfusion frequency. The platelet counts significantly increase after treatment with Papaya leaves extract.

Conclusions: Carica papaya leafs extract is effective ,safe and cheap for treatment of Bernard-Soulier syndrome. Further studies should put in consideration.

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ISTH Congress Abstracts - https://abstracts.isth.org/abstract/clinical-use-of-carica-papaya-leaf-extract-in-thrombocytopenia-in-bernard-soulier-syndrome/