Abstract Number: PB1063
Meeting: ISTH 2021 Congress
Background: In the clinical setting, APS can cause protean clinical manifestations apart from the classical symptoms. As a result, patients are referred for testing in a wide variety of scenarios. We conducted a study to identify the common clinical causes for which lupus testing is requested and also to assess the percentage positivity in different conditions.
Aims: To study the clinical pathological characterization of Anti phospholipid syndrome at a tertiary care hospital.
Methods: This study was carried out retrospectively in 130 patients referred for APS workup to the laboratory. LA was evaluated on the basis of either prolonged lupus sensitive APTT or dilute Russell Viper Venom Test (dRVVT). aCL and anti β2-GPI antibodies were measured with sandwich ELISA. The patient records were retrieved from the Hospital Information System.
Results: Out of the 130 cases, the indications for testing in decreasing order were patients with ITP, SLE, AIHA, thrombosis, pregnancy loss and other autoimmune diseases. 35 out of 130 patients were positive for LA with an M:F ratio of 2:5.
Conclusions: APS testing is done in several clinical scenarios. In our small retrospective analysis, we identified ITP as the most common cause for LA positivity. Further, this small study also highlights the lacunae in testing for other antibodies namely anti- β2 GPI and aCL.
|Indication for testing||Number of cases (%)|
|Immune thrombocytopenia (ITP)||10 (28.5%)|
|Systemic lupus erythematosus (SLE)||6 (17%)|
|Autoimmune hemolytic anemia (AIHA)||4 (11.4%)|
|Pregnancy loss||2 (5.7%)|
|Adult onset Stills’ disease||1 (2.8%)|
|Sjogren’s syndrome||1 (2.8%)|
|Autoimmune hepatitis||1 (2.8%)|
|Avascular necrosis||1 (2.8%)|
|Thrombotic microangiopathy||3 (8.5%)|
|Chronic liver disease||1 (2.8%)|
|Autoimmune thyroiditis||2 (5.7%)|
To cite this abstract in AMA style:Sajeeve K, V DK, V V, Catherine Jacob A, Sidharth D, Vidyadharan D. Clinico-pathologic Characterization of Patients Tested for Antiphospholipid Syndrome at a Tertiary Care Hospital [abstract]. Res Pract Thromb Haemost. 2021; 5 (Suppl 2). https://abstracts.isth.org/abstract/clinico-pathologic-characterization-of-patients-tested-for-antiphospholipid-syndrome-at-a-tertiary-care-hospital/. Accessed December 11, 2023.
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