Abstract Number: PB2268
Meeting: ISTH 2020 Congress
Background: Deep vein thrombosis (DVT) mainly occurs as a result of coagulation disorder in the large veins of the legs. It could reduce or abolish blood flow, and/or changes to the vessel wall. Thromboelastography (TEG) is a novel platform for evaluating coagulation status, and could monitor the whole process from coagulation to thrombosis then to thrombolysis.
Aims: To investigate the consistency between TEG and conventional coagulation tests (CCTs) in DVT.
Methods: A total of 142 patients with DVT were involved. The correlation and consistency analysis between TEG and CCTs were assessed by the Spearman correlation and Kappa value. Receiver operating characteristic curve was selected to analyze the predictive value of TEG for abnormal results of CCTs.
(1) The correlation between TEG and CCTs were shown in Table 1;
(2) R and PT value, R and TT value, K and PLT value, K and FIB value, Angle and FIB value, MA and PLT value, MA and FIB value were accordant in valuing the hypocoagulable state of DVT patients, respectively;
(3) R and APTT value, R and TT value, K and FIB value, Angle and TT value, Angle and FIB value, MA and PLT value, MA and FIB value were accordant in assessing hypercoagulable status of DVT patients, respectively;
(4) For detecting PT>14s, the area under the curve (AUC) of R was 0.671; For detecting PLT< 125×109/L, the AUC of K was 0.709; For detecting TT< 14s, the AUC of Angle and MA were 0.670, 0.671, respectively; For detecting FIB>4g/L, the AUC of Angle and MA were 0.715, 0.815 (Figure 1).
Conclusions: There was weak correlation and consistency between TEG and CCTs in DVT patients. The TEG have good predictive value in evaluating the abnormal results of CCTs. Combing the advantages of two methods will better reflect the coagulation status of DVT patients.
[Table 1 Correlation analysis between thromboelastography and conventional coagulation tests parameters in Deep vein thrombosis]
To cite this abstract in AMA style:Yan B, Du W, Hu T. Comparative Study between Thromboelastography and Conventional Coagulation Tests in Deep Vein Thrombosis [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1). https://abstracts.isth.org/abstract/comparative-study-between-thromboelastography-and-conventional-coagulation-tests-in-deep-vein-thrombosis/. Accessed January 23, 2022.
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